Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4568608 | 0.88 | KDM4E (0.43) | KDM4EMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL4568606 | 0.86 | KDM4E (0.42) | KDM4EMEN1KMT2AHSP90AA1GAA | |
| SCHEMBL4568607 | 0.85 | KDM4E (0.47) | KDM4EHSP90AA1POLBCA12CA1 | |
| SCHEMBL4572094 | 0.83 | MEN1 (0.49) | KDM4EMEN1KMT2AHSP90AA1GAA | |
| SCHEMBL8032408 | 0.73 | KDM4E (0.53) | KDM4EMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL3874678 | 0.72 | KDM4E (0.63) | KDM4EMEN1KMT2AHSP90AA1GAA | |
| SCHEMBL4572103 | 0.71 | CYP2C9 (0.51) | KDM4EMEN1KMT2ANPSR1MAPT | |
| SCHEMBL10057776 | 0.69 | MEN1 (0.45) | KDM4EMEN1KMT2ANPSR1MAPT | |
| SCHEMBL10056671 | 0.68 | KCNH2 (0.50) | KDM4EMEN1KMT2AACHE | |
| SCHEMBL4386263 | 0.65 | KDM4E (0.72) | KDM4EMEN1KMT2AHSP90AA1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8809343-B2 | Pyrimidine derivative, preparation method and use thereof | FUDAN UNIVERSITY (CN) | 2014-08-19 | — | — | US | disclosed |
| US-20120122902-A1 | PYRIMIDINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | FUDAN UNIVERSITY (CN) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122902-A1 | PYRIMIDINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | DPYD, TYMP, TYMS | KDM4E 1090/4885MEN1 3555/4885KMT2A 3566/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.