Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 5/20 | 0.38 |
| ▸ | MET | P08581 | 3/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | METAP1 | P53582 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4568608 | 0.85 | KDM4E (0.43) | KDM4EPTK2CA12CA1CA2 | |
| SCHEMBL4568612 | 0.85 | KDM4E (0.43) | KDM4ECA12CA1CA2CA9 | |
| SCHEMBL4568606 | 0.83 | KDM4E (0.42) | KDM4ECA12CA1CA2CA9 | |
| SCHEMBL10056671 | 0.82 | KCNH2 (0.50) | KDM4EPTK2KCNH2SCN5ASCN9A | |
| SCHEMBL8032408 | 0.76 | KDM4E (0.53) | KDM4ECA12CA1CA2CA9 | |
| SCHEMBL30949018 | 0.70 | MET (0.52) | PTK2PLK4KDRMETKCNH2 | |
| SCHEMBL4386263 | 0.68 | KDM4E (0.72) | KDM4ECA12CA1CA2CA9 | |
| SCHEMBL4572094 | 0.68 | MEN1 (0.49) | KDM4EHSP90AA1KCNH2SCN5ASCN9A | |
| SCHEMBL4572103 | 0.68 | CYP2C9 (0.51) | KDM4EKCNH2SCN5ASCN9AMAPT | |
| SCHEMBL10057776 | 0.66 | MEN1 (0.45) | KDM4EKCNH2SCN5ASCN9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8809343-B2 | Pyrimidine derivative, preparation method and use thereof | FUDAN UNIVERSITY (CN) | 2014-08-19 | — | — | US | disclosed |
| US-20120122902-A1 | PYRIMIDINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | FUDAN UNIVERSITY (CN) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122902-A1 | PYRIMIDINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | DPYD, TYMP, TYMS | KDM4E 1090/4885PTK2 4600/4885PLK4 1701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.