SCHEMBL4569102

SCHEMBL4569102

NCC/C(=N/N)c1cccc(OCC2CCCCC2)c1

nearest known ligand 0.57

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
KAT6A Q92794 1/20 0.49
SIRT2 Q8IXJ6 1/20 0.47
PARP10 Q53GL7 4/20 0.45
PARP15 Q460N3 3/20 0.45
NR1H4 Q96RI1 1/20 0.45
TLR4 O00206 1/20 0.43
TLR2 O60603 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2208472 1.00 KAT6A (0.49) KAT6ASIRT2PARP10PARP15NR1H4
SCHEMBL2208476 1.00 KAT6A (0.49) KAT6ASIRT2PARP10PARP15NR1H4
SCHEMBL4568815 0.90 KAT6A (0.45) KAT6ASIRT2PARP10PARP15NR1H4
SCHEMBL17031422 0.90 KAT6A (0.45) KAT6ASIRT2PARP10PARP15NR1H4
SCHEMBL20332000 0.89 KAT6A (0.46) KAT6ASIRT2PARP10PARP15NR1H4
SCHEMBL18550944 0.88 KAT6A (0.45) KAT6ASIRT2PARP10PARP15NR1H4
SCHEMBL25823093 0.84 KAT6A (0.43) KAT6ASIRT2PARP10PARP15TLR4
SCHEMBL2207567 0.83 KAT6A (0.49) KAT6ASIRT2PARP10PARP15NR1H4
SCHEMBL19291604 0.82 KAT6A (0.47) KAT6ASIRT2PARP10PARP15NR1H4
SCHEMBL8899070 0.82 KAT6A (0.48) KAT6ASIRT2PARP10PARP15NR1H4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230218549-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2023-07-13 US disclosed
US-20210077427-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2021-03-18 US disclosed
US-10639286-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2020-05-05 US disclosed
US-20190183816-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2019-06-20 US disclosed
US-10188615-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2019-01-29 US disclosed
US-20180177746-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2018-06-28 US disclosed
US-20180177746-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2018-06-28 US disclosed
EP-3210966-A1 ALKOXYPHENYLPROPYLAMINES FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION Acucela, Inc. (US) 2017-08-30 EP disclosed
US-9737496-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2017-08-22 US disclosed
US-9737496-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2017-08-22 US disclosed
US-20120214852-A1 Alkoxy Compounds for Disease Treatment ACUCELA INC. (US) 2012-08-23 US disclosed
US-20120129894-A1 Alkoxy Compounds for Disease Treatment ACUCELA INC. (US) 2012-05-24 US disclosed
US-20120129894-A1 Alkoxy Compounds for Disease Treatment ACUCELA INC. (US) 2012-05-24 US disclosed
US-20120122938-A1 Alkoxy Compounds for Disease Treatment ACUCELA INC. (US) 2012-05-17 US disclosed
US-20120122938-A1 Alkoxy Compounds for Disease Treatment ACUCELA INC. (US) 2012-05-17 US disclosed
US-7982071-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2011-07-19 US disclosed
US-7982071-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2011-07-19 US disclosed
US-20090326074-A1 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2009-12-31 US disclosed
US-20090326074-A1 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2009-12-31 US disclosed
WO-2009045479-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. (US) 2009-04-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120122938-A1 Alkoxy Compounds for Disease Treatment ALDH1A2, CLN6, AGER KAT6A 1820/4885SIRT2 923/4885PARP10 1814/4885
US-20210077427-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER KAT6A 1820/4885SIRT2 923/4885PARP10 1814/4885
US-20230218549-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER KAT6A 1794/4885SIRT2 903/4885PARP10 1846/4885
US-20190183816-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER KAT6A 1820/4885SIRT2 923/4885PARP10 1814/4885
US-20120214852-A1 Alkoxy Compounds for Disease Treatment ALDH1A2, CLN6, AGER KAT6A 1820/4885SIRT2 923/4885PARP10 1814/4885
US-20090326074-A1 Alkoxy compounds for disease treatment ALDH1A2, CLN6, AGER KAT6A 1820/4885SIRT2 923/4885PARP10 1814/4885
US-10188615-B2 Alkoxy compounds for disease treatment ALDH1A2, CLN6, AGER KAT6A 1820/4885SIRT2 923/4885PARP10 1814/4885
US-20180177746-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER KAT6A 1820/4885SIRT2 923/4885PARP10 1814/4885
US-20120129894-A1 Alkoxy Compounds for Disease Treatment ALDH1A2, CLN6, AGER KAT6A 1820/4885SIRT2 923/4885PARP10 1814/4885
US-10639286-B2 Alkoxy compounds for disease treatment ALDH1A2, CLN6, AGER KAT6A 1820/4885SIRT2 923/4885PARP10 1814/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.