Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR1E | P28566 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL474802 | 0.87 | ALPL (0.54) | CA12ALPLMKNK1MKNK2MAPT | |
| SCHEMBL14731247 | 0.74 | HPGD (0.54) | MAPTNPSR1L3MBTL1KMT2ANPC1 | |
| SCHEMBL28466328 | 0.73 | ALPL (0.58) | CA12ALPLMAPTL3MBTL1KMT2A | |
| Tert-Butyl Formate SCHEMBL27799796 | 0.71 | MAPT (0.46) | CA12ALPLMKNK1MKNK2MAPT | |
| Hydrochloric Acid SCHEMBL9124767 | 0.71 | ALPL (0.56) | CA12ALPLMAPTL3MBTL1KMT2A | |
| SCHEMBL3339364 | 0.71 | IKBKE (0.38) | CA12ALPLMKNK1MKNK2MAPT | |
| SCHEMBL14726281 | 0.70 | CASP1 (0.44) | MAPTLMNAHPGDTP53 | |
| SCHEMBL2598428 | 0.70 | MKNK1 (0.74) | MKNK1MKNK2MAPTNPSR1DRD4 | |
| SCHEMBL244618 | 0.70 | ALPL (0.54) | CA12ALPLMKNK1MKNK2MAPT | |
| SCHEMBL1143098 | 0.70 | SMN1; SMN2 (0.61) | ALPLMAPTNPSR1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118067-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | Siena Biotech S.p.A. (IT) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008087529-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | SIENA BIOTECH S.P.A. (IT) | 2008-07-24 | — | — | WO | disclosed |