Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.39 |
| ▸ | IGF1R | P08069 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 4/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | RBP4 | P02753 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3695866 | 0.84 | ALDH1A1 (0.42) | ALDH1A1EPHB4IGF1RMEN1KMT2A | |
| SCHEMBL4569774 | 0.83 | IGF1R (0.42) | ALDH1A1EPHB4IGF1RMEN1KMT2A | |
| SCHEMBL3707818 | 0.82 | ALDH1A1 (0.46) | ALDH1A1EPHB4IGF1RMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL3699244 | 0.82 | ALDH1A1 (0.45) | ALDH1A1EPHB4IGF1RMEN1KMT2A | |
| SCHEMBL3707545 | 0.78 | IGF1R (0.48) | ALDH1A1IGF1RMEN1KMT2AMAPT | |
| SCHEMBL15077854 | 0.76 | ALDH1A1 (0.38) | ALDH1A1EPHB4IGF1RMEN1KMT2A | |
| SCHEMBL256206 | 0.76 | ALDH1A1 (0.57) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL15052734 | 0.75 | ALDH1A1 (0.44) | ALDH1A1EPHB4IGF1RMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL15052409 | 0.75 | ALDH1A1 (0.44) | ALDH1A1EPHB4IGF1RMEN1KMT2A | |
| SCHEMBL3701262 | 0.74 | KDM4E (0.42) | ALDH1A1MEN1KMT2AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8648086-B2 | 5,6-bicyclic heteroaryl-containing urea compounds as kinase inhibitors | ASCEPION PHARMACEUTICALS, INC. (CN) | 2014-02-11 | — | — | US | disclosed |
| US-20120122895-A1 | 5,6-BICYCLIC HETEROARYL-CONTAINING UREA COMPOUNDS AS KINASE INHIBITORS | JIANG, SHAN | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122895-A1 | 5,6-BICYCLIC HETEROARYL-CONTAINING UREA COMPOUNDS AS KINASE INHIBITORS | FLT3, CSF1R, EPHA2 | ALDH1A1 1084/4885EPHB4 33/4885IGF1R 41/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.