Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 12/20 | 0.60 |
| ▸ | GSK3B | P49841 | 11/20 | 0.60 |
| ▸ | GSK3A | P49840 | 10/20 | 0.60 |
| ▸ | KDR | P35968 | 6/20 | 0.60 |
| ▸ | CLK2 | P49760 | 6/20 | 0.60 |
| ▸ | STK17A | Q9UEE5 | 5/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.60 |
| ▸ | DYRK3 | O43781 | 4/20 | 0.60 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.60 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.60 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.60 |
| ▸ | CDK2 | P24941 | 3/20 | 0.60 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.60 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.60 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.60 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.60 |
| ▸ | BRSK1 | Q8TDC3 | 2/20 | 0.60 |
| ▸ | SGK2 | Q9HBY8 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3800759 | 0.80 | CLK4 (0.59) | CLK4GSK3BGSK3AKDRCLK2 | |
| SCHEMBL4569972 | 0.76 | CLK4 (0.61) | CLK4GSK3BGSK3AKDRCLK2 | |
| SCHEMBL3795773 | 0.76 | CLK4 (0.74) | CLK4GSK3BGSK3AKDRCLK2 | |
| SCHEMBL27299059 | 0.75 | CLK4 (0.63) | CLK4GSK3BGSK3AKDRCLK2 | |
| SCHEMBL3802860 | 0.75 | CLK4 (1.00) | CLK4GSK3BGSK3AKDRCLK2 | |
| SCHEMBL3798480 | 0.74 | CLK4 (0.71) | CLK4GSK3BGSK3AKDRCLK2 | |
| SCHEMBL10008456 | 0.73 | CLK4 (1.00) | CLK4GSK3BGSK3AKDRCLK2 | |
| SCHEMBL5240032 | 0.69 | CLK4 (0.55) | CLK4GSK3BGSK3AKDRCLK2 | |
| SCHEMBL4418122 | 0.68 | CLK4 (0.54) | CLK4GSK3BGSK3AKDRCLK2 | |
| SCHEMBL7375370 | 0.68 | CLK4 (0.50) | CLK4GSK3BGSK3AKDRCLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091943-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS GLYCOGEN SYNTHASE KINASE 3 INHIBITORS | Abbott GmbH & Co. KG (DE) | 2009-08-26 | — | — | EP | disclosed |
| WO-2008046919-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS GLYCOGEN SYNTHASE KINASE 3 INHIBITORS | ABBOTT GMBH & CO. KG (DE) | 2008-04-24 | — | — | WO | disclosed |