Puromycin

Puromycin

SCHEMBL4570

COc1ccc(C[C@H](N)C(=O)N[C@H]2[C@@H](O)[C@H](n3cnc4c(N(C)C)ncnc43)O[C@@H]2CO)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
NPEPPS P55786 12/20 1.00
ANPEP P15144 10/20 1.00
SMN1; SMN2 Q16637 3/20 1.00
TP53 P04637 2/20 1.00
CYP3A4 P08684 2/20 1.00
LMNA P02545 1/20 1.00
HIF1A Q16665 1/20 1.00
HTT P42858 1/20 0.99
NPC1 O15118 1/20 0.99
RAB9A P51151 1/20 0.99
PAX8 Q06710 1/20 0.99
SLC29A1 Q99808 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Puromycin SCHEMBL14583797 1.00 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL20393806 1.00 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL14583945 1.00 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL22409382 1.00 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL3042415 1.00 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL21306559 1.00 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL24206459 1.00 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL20815730 1.00 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL22348910 1.00 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL21481061 1.00 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 140664 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260146259-A1 COMPOSITIONS AND SYSTMES FOR HERPES SIMPLEX VIRUS PACKAGING AND USES THEREOF Opentrons LabWorks Inc. (US) 2026-05-28 US claimed
EP-4748859-A2 CHEMICALLY AND PHOTOCHEMICALLY INITIATED CELL MEMBRANE BLEBBING TO INDUCE CELL VESICLE PRODUCTION, MODIFICATIONS THEREOF, AND USES THEREOF The Regents of the University of California (US) 2026-05-27 EP claimed
EP-4746924-A1 NON-NATURAL BUILDING BLOCKS FOR ENHANCED TRANSLATION AND STABILITY OF MRNA Eleven Therapeutics Ltd (IL) 2026-05-27 EP claimed
CN-122080230-A Nano decoy receptor for blocking IL-17 signal path and preparation method and application thereof 2026-05-26 CN claimed
CN-122081237-A Engineered enucleated mesenchymal stem cells, and preparation method and application thereof 2026-05-26 CN claimed
CN-122081332-A ShRNA for silencing KAT8 and application thereof 2026-05-26 CN claimed
CN-122081407-A Integrin alpha 6 stable low-expression lung cancer cell strain and construction method thereof 2026-05-26 CN claimed
CN-122081224-A Method for constructing humanized brain organoid model of early-onset Alzheimer disease and application of humanized brain organoid model 2026-05-26 CN claimed
CN-122081406-A Virus vector for inhibiting angiogenesis by targeting KIF4A as well as preparation method and application thereof 2026-05-26 CN claimed
WO-2026103922-A1 CHIMERIC SHUTTLING RECEPTOR 深圳市湾岛细胞科技有限公司 2026-05-21 WO claimed
EP-0409406-A2 Aryl-substituted amine derivatives useful in cancer therapy THE WELLCOME FOUNDATION LIMITED (GB) 1991-01-23 EP claimed
WO-1990015599-A1 MEDICAMENTS USEFUL IN CANCER THERAPY AND HAVING ANTIHISTAMINIC PROPERTIES THE WELLCOME FOUNDATION LIMITED (GB) 1990-12-27 WO claimed
WO-1990008584-A1 NOVEL AMINOGLYCOSIDE AFFINITY MEDIA FOR SEPARATION OF MACROMOLECULES THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, UNITED STATES DEPARTMENT OF COMMERCE (US) 1990-08-09 WO claimed
EP-0332104-A2 Chemically regulatable DNA sequences and genes and uses thereof CIBA-GEIGY AG (CH) 1989-09-13 EP claimed
US-4753984-A Water soluble macromolecular prodrugs, their preparation and their use as antitumor and antiparasite medicines CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) 1988-06-28 US claimed
EP-0245063-A1 Eukaryotic resistance markers Antibioticos S.A. (ES) 1987-11-11 EP claimed
WO-1987006612-A1 EUKARYOTIC RESISTANCE MARKERS ABLEWHITE, ALAN, JAMES (GB) 1987-11-05 WO claimed
US-4617293-A Flavonoid phosphate salts of aminoglycoside antibiotics MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) 1986-10-14 US claimed
EP-0174810-A2 Multidrug resistance in mammalian cell lines and isolation of determinant glycoprotein DNA HSC Research Development Corporation (CA) 1986-03-19 EP claimed
US-4148887-A SUGAR ESTER WITH A METHYL SULFOXIDE THE PROCTER & GAMBLE COMPANY (US) 1979-04-10 US claimed