Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM6B | O15054 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.44 |
| ▸ | RECQL | P46063 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL174846 | 1.00 | KDM6B (0.51) | KDM6BSMN1; SMN2KDM4ETDP1HSD17B10 | |
| SCHEMBL4570541 | 0.83 | KDM6B (0.39) | KDM6BSMN1; SMN2KDM4ETDP1HSD17B10 | |
| Dopamine SCHEMBL28740409 | 0.81 | KDM4E (0.62) | KDM6BSMN1; SMN2KDM4ETDP1HSD17B10 | |
| Succinic Acid SCHEMBL175593 | 0.78 | KDM4E (0.53) | SMN1; SMN2KDM4ETDP1HSD17B10MAPT | |
| Malic Acid SCHEMBL21145140 | 0.77 | SMN1; SMN2 (0.60) | SMN1; SMN2TDP1CYP2C19LMNAPOLB | |
| Malic Acid SCHEMBL21145138 | 0.77 | SMN1; SMN2 (0.60) | SMN1; SMN2TDP1CYP2C19LMNAPOLB | |
| Propionic Acid SCHEMBL13730113 | 0.77 | KDM4E (0.52) | SMN1; SMN2KDM4ETDP1HSD17B10MAPT | |
| Malic Acid SCHEMBL27754520 | 0.76 | SMN1; SMN2 (0.54) | SMN1; SMN2TDP1HSD17B10CYP3A4MEN1 | |
| Malic Acid SCHEMBL28829049 | 0.74 | SMN1; SMN2 (0.68) | KDM6BSMN1; SMN2SLC7A5KMO | |
| Acetic Acid SCHEMBL27477102 | 0.74 | KDM4E (0.57) | SMN1; SMN2KDM4ETDP1HSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017848-A9 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF AMYLOID DISEASES SUCH AS SYSTEMIC AA AMYLOIDOSIS | PROTEO TECH INC (US) | 2009-04-30 | — | — | WO | disclosed |
| WO-2009017848-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF AMYLOID DISEASES SUCH AS SYSTEMIC AA AMYLOIDOSIS | PROTEO TECH INC. (US) | 2009-02-05 | — | — | WO | disclosed |