Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.46 |
| ▸ | KMO | O15229 | 1/20 | 0.46 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.44 |
| ▸ | TET2 | Q6N021 | 3/20 | 0.41 |
| ▸ | TET3 | O43151 | 1/20 | 0.41 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.41 |
| ▸ | KDM6B | O15054 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA3 | P07451 | 1/20 | 0.41 |
| ▸ | TYR | P14679 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Paraben SCHEMBL28145503 | 0.90 | CA2 (0.59) | SMN1; SMN2CA2KMOCA12CA1 | |
| Malic Acid SCHEMBL31489076 | 0.85 | SMN1; SMN2 (0.83) | SMN1; SMN2KMOTET2TET3TET1 | |
| Malic Acid SCHEMBL27794963 | 0.83 | SMN1; SMN2 (0.88) | SMN1; SMN2KMOTET2TET3TET1 | |
| Malic Acid SCHEMBL31673489 | 0.83 | — | — | |
| Malic Acid SCHEMBL98496 | 0.83 | — | — | |
| Malic Acid SCHEMBL31673494 | 0.83 | — | — | |
| Malic Acid SCHEMBL28355917 | 0.83 | SMN1; SMN2 (1.00) | SMN1; SMN2KMOTET2TET3TET1 | |
| Malic Acid SCHEMBL856 | 0.83 | — | — | |
| Malic Acid SCHEMBL89131 | 0.83 | SMN1; SMN2 (1.00) | SMN1; SMN2KMOTET2TET3TET1 | |
| Malic Acid SCHEMBL256122 | 0.83 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103882484-B | High-speed tin plating plating solution | 哈尔滨工业大学 | 2016-06-29 | — | — | CN | disclosed |