Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM6B | O15054 | 1/20 | 0.39 |
| ▸ | JUN | P05412 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.36 |
| ▸ | MAPT | P10636 | 7/20 | 0.36 |
| ▸ | RECQL | P46063 | 5/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.36 |
| ▸ | GAA | P10253 | 4/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL4570540 | 0.83 | KDM6B (0.51) | KDM6BKDM4ETDP1MAPTRECQL | |
| Malic Acid SCHEMBL174846 | 0.83 | KDM6B (0.51) | KDM6BKDM4ETDP1MAPTRECQL | |
| SCHEMBL24430 | 0.78 | SMN1; SMN2 (0.52) | TDP1ALOX15LMNASMN1; SMN2 | |
| SCHEMBL1179759 | 0.78 | SMN1; SMN2 (0.52) | TDP1ALOX15LMNASMN1; SMN2 | |
| Ammonia Solution, Strong SCHEMBL2586848 | 0.76 | SMN1; SMN2 (0.50) | TDP1LMNASMN1; SMN2 | |
| Malic Acid SCHEMBL14125843 | 0.75 | SMN1; SMN2 (0.60) | TDP1LMNASMN1; SMN2 | |
| SCHEMBL29144651 | 0.70 | SMN1; SMN2 (0.41) | TDP1LMNAMMP1SMN1; SMN2 | |
| SCHEMBL27705704 | 0.70 | SMN1; SMN2 (0.41) | TDP1LMNAMMP1SMN1; SMN2 | |
| SCHEMBL16421124 | 0.70 | KDM6B (0.67) | KDM6BJUNKDM4ETDP1MAPT | |
| Succinic Acid SCHEMBL175593 | 0.69 | KDM4E (0.53) | KDM4ETDP1MAPTRECQLHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017848-A9 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF AMYLOID DISEASES SUCH AS SYSTEMIC AA AMYLOIDOSIS | PROTEO TECH INC (US) | 2009-04-30 | — | — | WO | disclosed |
| WO-2009017848-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF AMYLOID DISEASES SUCH AS SYSTEMIC AA AMYLOIDOSIS | PROTEO TECH INC. (US) | 2009-02-05 | — | — | WO | disclosed |