Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 3/20 | 0.40 |
| ▸ | ICAM1 | P05362 | 3/20 | 0.40 |
| ▸ | ITGAL | P20701 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | ALB | P02768 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.36 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL551858 | 0.82 | ALB (0.47) | ITGB2ICAM1ITGALPOLBALB | |
| SCHEMBL550567 | 0.75 | POLB (0.47) | ITGB2ICAM1ITGALPOLBALB | |
| SCHEMBL6028213 | 0.74 | KDM4E (0.41) | ITGB2ICAM1ITGALPOLBPTPN1 | |
| SCHEMBL5657142 | 0.72 | MEN1 (0.43) | POLBLMNAMEN1KMT2A | |
| SCHEMBL5657918 | 0.72 | ALDH1A1 (0.52) | POLBHTTLMNAGAAMEN1 | |
| SCHEMBL551859 | 0.71 | PTPN1 (0.48) | ITGB2ICAM1ITGALPOLBPTPN1 | |
| SCHEMBL7135256 | 0.70 | ITGB2 (0.53) | ITGB2ICAM1ITGALTP53HTT | |
| SCHEMBL852026 | 0.69 | ALB (0.52) | POLBALBLMNAGAAL3MBTL1 | |
| SCHEMBL28472994 | 0.68 | POLB (0.38) | ITGB2ICAM1ITGALPOLBALB | |
| SCHEMBL335939 | 0.67 | ALB (0.63) | ALBLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2591354-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |