Sugi Predict

Sugi Predict / Compounds / SCHEMBL4570738

SCHEMBL4570738

SCHEMBL4570738

CC(C)(C)c1cc(N2CC[C@@](C)(S(=O)(=O)c3ccc(Cl)cc3)C2=O)on1

nearest known ligand 0.38

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ CNR2 P34972 6/20 0.36
▸ MAPK14 Q16539 1/20 0.35
▸ CNR1 P21554 3/20 0.35
▸ EEF2K O00418 1/20 0.35
▸ SMN1; SMN2 Q16637 3/20 0.34
▸ LMNA P02545 2/20 0.34
▸ ALDH1A1 P00352 1/20 0.34
▸ PSEN1 P49768 2/20 0.34
▸ PSEN2 P49810 2/20 0.34
▸ APH1B Q8WW43 2/20 0.34
▸ NCSTN Q92542 2/20 0.34
▸ APH1A Q96BI3 2/20 0.34
▸ PSENEN Q9NZ42 2/20 0.34
▸ MAPT P10636 1/20 0.34
▸ GAA P10253 1/20 0.34
▸ THRB P10828 1/20 0.33
▸ MEN1 O00255 1/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ ATM Q13315 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4570737 1.00 CNR2 (0.36) CNR2MAPK14CNR1EEF2KSMN1; SMN2
SCHEMBL1785466 1.00 CNR2 (0.36) CNR2MAPK14CNR1EEF2KSMN1; SMN2
SCHEMBL1787389 0.82 CNR2 (0.43) CNR2CNR1EEF2KSMN1; SMN2LMNA
SCHEMBL15292122 0.79 MAPK14 (0.34) CNR2MAPK14CNR1
SCHEMBL1785664 0.76 CNR2 (0.36) CNR2CNR1
SCHEMBL4570728 0.73 EEF2K (0.45) EEF2KSMN1; SMN2LMNAALDH1A1PSEN1
SCHEMBL4570735 0.69 L3MBTL1 (0.50) SMN1; SMN2ALDH1A1MAPTGAA
SCHEMBL4570736 0.69 NEK2 (0.37) EEF2KSMN1; SMN2LMNAALDH1A1PSEN1
SCHEMBL15292135 0.67 CNR2 (0.37) CNR2CNR1
SCHEMBL4570732 0.66 FAAH (0.43) LMNAPSEN1PSEN2APH1BNCSTN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2326629-B1 SULFONE COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR BOEHRINGER INGELHEIM INT (DE) 2013-10-02 — — EP disclosed
US-8178568-B2 Sulfone compounds which modulate the CB2 receptor BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2012-05-15 — — US disclosed
US-8178568-B2 Sulfone compounds which modulate the CB2 receptor BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2012-05-15 — — US disclosed
US-20110124696-A1 Sulfone Compounds Which Modulate The CB2 Receptor BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-05-26 — — US disclosed
US-20110124696-A1 Sulfone Compounds Which Modulate The CB2 Receptor BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-05-26 — — US disclosed
WO-2010005782-A1 SULFONE COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2010-01-14 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110124696-A1 Sulfone Compounds Which Modulate The CB2 Receptor CNR2, CNR1, TRPV1 CNR2 1/4885MAPK14 1347/4885CNR1 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.