Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.69 |
| ▸ | HPGD | P15428 | 3/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALPL | P05186 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22422905 | 0.94 | SMN1; SMN2 (0.61) | HTTSMN1; SMN2HPGDALDH1A1TSHR | |
| SCHEMBL21120300 | 0.86 | HTT (0.65) | HTTSMN1; SMN2HPGDALDH1A1TSHR | |
| SCHEMBL25734966 | 0.85 | HTT (0.73) | HTTSMN1; SMN2HPGDALDH1A1TSHR | |
| SCHEMBL23346430 | 0.85 | HTT (0.68) | HTTSMN1; SMN2HPGDALDH1A1TSHR | |
| SCHEMBL20034931 | 0.85 | HTT (0.64) | HTTSMN1; SMN2HPGDALDH1A1TSHR | |
| SCHEMBL9999886 | 0.83 | PTGS1 (0.54) | HTTSMN1; SMN2HPGDALDH1A1KDM4E | |
| SCHEMBL26005683 | 0.82 | SMN1; SMN2 (0.68) | HTTSMN1; SMN2HPGDALDH1A1TSHR | |
| SCHEMBL25973101 | 0.82 | SMN1; SMN2 (0.48) | HTTSMN1; SMN2HPGDALDH1A1KDM4E | |
| SCHEMBL10044365 | 0.82 | SMN1; SMN2 (0.85) | HTTSMN1; SMN2HPGDALDH1A1TSHR | |
| SCHEMBL19756303 | 0.82 | SMN1; SMN2 (0.62) | HTTSMN1; SMN2HPGDALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120164635-A1 | LARGE STOKE SHIFT NIR DYES | VANDERBILT UNIVERSITY | 2012-06-28 | — | — | US | disclosed |
| US-8168804-B2 | Large stoke shift NIR dyes | VANDERBILT UNIVERSITY (US) | 2012-05-01 | — | — | US | disclosed |
| US-20090029405-A1 | LARGE STOKE SHIFT NIR DYES | VANDERBILT UNIVERSITY | 2009-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120164635-A1 | LARGE STOKE SHIFT NIR DYES | SLC7A5, SLC43A1, SPIN3 | HTT 3647/4885SMN1; SMN2 1050/4885HPGD 3230/4885 |
| US-20090029405-A1 | LARGE STOKE SHIFT NIR DYES | SLC7A5, SLC43A1, SPIN3 | HTT 3647/4885SMN1; SMN2 1050/4885HPGD 3230/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.