SPIN3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL29369030	1.00	1/20
SCHEMBL19385205	0.58	1/20
SCHEMBL29937017	0.58	1/20
SCHEMBL2953260	0.56	1/20
SCHEMBL28894304	0.55	1/20
SCHEMBL19385373	0.55	1/20
SCHEMBL1089104	0.55	1/20
SCHEMBL1089641	0.54	1/20
SCHEMBL1089644	0.54	1/20
SCHEMBL1090089	0.54	1/20
SCHEMBL19385129	0.53	1/20
SCHEMBL25244226	0.53	1/20
SCHEMBL28894334	0.53	1/20
SCHEMBL19385236	0.52	1/20
SCHEMBL19385261	0.52	1/20
SCHEMBL19405236	0.52	1/20
SCHEMBL25202485	0.52	1/20
SCHEMBL19385009	0.52	1/20
SCHEMBL23015382	0.51	1/20
SCHEMBL19385024	0.51	1/20

Clinical trials — most relevant to SPIN3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Cornelia De Lange Syndrome: Assessing Positive Effects of Lithium Treatment	PHASE2/PHASE3	RECRUITING
A Research Study Looking at How Safe Somapacitan is and How Well it Works in Children Who Need Help to Grow - REAL 9	PHASE3	ACTIVE_NOT_RECRUITING
A Safety and Pharmacokinetics Trial of VO659 in SCA1, SCA3 and HD	PHASE1/PHASE2	RECRUITING
Efficacy and Safety Assessment of Oral LBH589 in Adult Patients With Advanced Soft TIssue Sarcoma After Pre-treatment Failure	PHASE2	COMPLETED
Phase I Study of SC-43 Oral Solution in Subjects With Refractory Solid Tumors	PHASE1	WITHDRAWN
A Review of the Management and Outcomes of Children With SMA in the West Midlands During 2017-2022	nan	UNKNOWN
Hemolysis in Patients With Hereditary Spherocytosis (HS)	nan	UNKNOWN
Idiopathic Scoliosis New Onset and Melatonin Phase Delay in Children	nan	RECRUITING
Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic Leukemia	nan	NOT_YET_RECRUITING
Analysis of Post-Translational Modifications of a Critical Protein Implicated in Amyotrophic Lateral Sclerosis	nan	COMPLETED
Treatment of Adolescent Idiopathic Scoliosis with the Schroth Method	nan	COMPLETED
Study of Synapsis and Recombination in Male Meiosis and the Implications in Infertility	nan	COMPLETED
A Patient-tailored Genetic/Biomarker/iPSC Combined Approach in ALS - PERMEALS	nan	RECRUITING
Exercises in Adolescent Idiopathic Scoliosis	nan	COMPLETED
A Study on Psychopathological Progress of Early Schizophrenia-Like Disorder (SOPRES)	nan	UNKNOWN
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA	nan	RECRUITING
Amplification of Zinc Finger Protein 217 Gene in Multiple Myeloma	nan	UNKNOWN
Biocollection in MyeloDysplastic Syndrome (P-MDS)	nan	RECRUITING
Improving Genetic Counseling for Patients With Spina Bifida Using Next Generation Sequencing	nan	COMPLETED
Implementation of FEES in Spinal Muscle Atrophy	nan	COMPLETED
Multicenter Study of Patients With SHANK3 Mutations: Identification of Genes Modificators in Phelan-McDermid Syndrome (EUQ13)	nan	NOT_YET_RECRUITING
SMYD3-Driven Metabolic Rewiring in Colorectal Liver Metastases	nan	NOT_YET_RECRUITING
Adrenal& Bone Complications in Paediatric Patients Living With Spinal Muscular Atrophy (SMA)	nan	NOT_YET_RECRUITING
The Natural History of Patients With Mutations in SEPN1 (SELENON) or LAMA2	nan	COMPLETED
Role of Inflammasome in Platelet Activation in Sickle Cell Disease Patient	nan	COMPLETED
Personalized Medicine Program on Myelodysplastic Syndromes: Characterization of the Patient's Genome for Clinical Decision Making and Systematic Collection of Real World Data to Improve Quality of Health Care	nan	COMPLETED
Investigation on the Prevalence and Etiology of Adolescent Idiopathic Scoliosis in Nanchang Region	nan	NOT_YET_RECRUITING
Docosahexaenoic Acid (DHA) Replacement for Treatment in Spinocerebellar Ataxia 38	nan	COMPLETED
Astrocytic Markers and the Pre-ataxic Period of SCA3/MJD - BIGPRO Study Astrocytes	nan	UNKNOWN
Better Delineation of CDK13 Related Phenotype and Epigenetic Signature.	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a SPIN3 binder may also engage these)

Protein	Name	Similarity
Q5RA80	—	1.000	Q5RA80 →
Q99865	—	0.997	Q99865 →
Q5RAW7	—	0.997	Q5RAW7 →
SPIN2B	Spindlin-2B	0.992	landscape →
Q61142	—	0.990	Q61142 →
Q90WG1	—	0.989	Q90WG1 →
Q5R997	—	0.988	Q5R997 →
SPIN1	Spindlin-1	0.988	landscape →
Q4V8J7	—	0.988	Q4V8J7 →
Q90WG2	—	0.988	Q90WG2 →
Q6NVE3	—	0.982	Q6NVE3 →
Q2KI39	—	0.968	Q2KI39 →
SPIN4	Spindlin-4	0.952	landscape →
Q8K1L2	—	0.944	Q8K1L2 →
Q0J035	—	0.940	Q0J035 →
A6H7H7	—	0.940	A6H7H7 →
A7X672	—	0.939	A7X672 →
Q80U70	—	0.938	Q80U70 →
Q9SFV2	—	0.937	Q9SFV2 →
D2XV59	—	0.936	D2XV59 →
P37285	—	0.935	P37285 →
Q5SWU9	—	0.935	Q5SWU9 →
Q8L5Y9	—	0.935	Q8L5Y9 →
Q4R8N2	—	0.935	Q4R8N2 →
Q9UK99	—	0.934	Q9UK99 →
Q9Y2S7	—	0.934	Q9Y2S7 →
Q07866	—	0.934	Q07866 →
P11497	—	0.934	P11497 →
ACACA	Acetyl-CoA carboxylase 1	0.933	landscape →
O00178	—	0.933	O00178 →