Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 2/20 | 0.69 |
| ▸ | GRM6 | O15303 | 2/20 | 0.69 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.69 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.69 |
| ▸ | GSR | P00390 | 2/20 | 0.69 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.69 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.69 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.69 |
| ▸ | GRM5 | P41594 | 1/20 | 0.69 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.69 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.69 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.69 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.69 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.69 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.69 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.69 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.69 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.69 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glutamic Acid SCHEMBL457312 | 1.00 | GRM8 (0.69) | GRM8GRM6GRM7GRM4GSR | |
| (S)-2-Aminoadipic Acid SCHEMBL29106852 | 0.92 | GSR (0.57) | GRM8GRM6GRM7GRM4GSR | |
| D-Glutamate SCHEMBL5076309 | 0.90 | GSR (0.86) | GRM8GRM6GRM7GRM4GSR | |
| Glutamic Acid SCHEMBL5076310 | 0.90 | GSR (0.86) | GRM8GRM6GRM7GRM4GSR | |
| (S)-2-Aminoadipic Acid SCHEMBL29106848 | 0.89 | GSR (0.53) | GRM8GRM6GRM7GRM4GSR | |
| Glutamic Acid SCHEMBL148727 | 0.88 | GRM8 (0.75) | GRM8GRM6GRM7GRM4GSR | |
| D-Glutamate SCHEMBL148726 | 0.88 | GRM8 (0.75) | GRM8GRM6GRM7GRM4GSR | |
| D-Glutamate SCHEMBL6138602 | 0.88 | GRM8 (0.75) | GRM8GRM6GRM7GRM4GSR | |
| Lysine SCHEMBL2020671 | 0.86 | GSR (0.67) | GRM8GRM6GRM7GRM4GSR | |
| Lysine SCHEMBL2020669 | 0.86 | GSR (0.67) | GRM8GRM6GRM7GRM4GSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190091300-A1 | METHODS OF TREATING CANCER OF THE CENTRAL NERVOUS SYSTEM | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2019-03-28 | — | — | US | disclosed |
| US-10159717-B2 | Methods of treating cancer of the central nervous system | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2018-12-25 | — | — | US | disclosed |
| US-20150216949-A1 | METHODS OF TREATING CANCER OF THE CENTRAL NERVOUS SYSTEM | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2015-08-06 | — | — | US | disclosed |
| US-9034319-B2 | Methods of treating cancer of the central nervous system | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2015-05-19 | — | — | US | disclosed |
| US-20120231512-A1 | PREPARATION OF ALPHA-KETOPIMELIC ACID | DSM IP ASSETS B.V. (NL) | 2012-09-13 | — | — | US | disclosed |
| US-20120156737-A1 | PREPARATION OF ALPHA-KETOPIMELIC ACID | DSM IP ASSETS B.V. (NL) | 2012-06-21 | — | — | US | disclosed |
| WO-2012031911-A2 | PREPARATION OF 6-AMINOCAPROIC ACID FROM ALPHA-KETOPIMELIC ACID | DSM IP ASSETS B.V. (NL) | 2012-03-15 | — | — | WO | disclosed |
| EP-2406384-A2 | PREPARATION OF ALPHA-KETOPIMELIC ACID | DSM IP Assets B.V. (NL) | 2012-01-18 | — | — | EP | disclosed |
| US-20110070218-A1 | METHODS OF TREATING CANCER OF THE CENTRAL NERVOUS SYSTEM | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2011-03-24 | — | — | US | disclosed |
| WO-2011031147-A1 | PREPARATION OF A COMPOUND COMPRISING AN AMINE GROUP FROM AN ALPHA-KETO ACID | DSM IP ASSETS B.V. (NL) | 2011-03-17 | — | — | WO | disclosed |
| WO-2011031146-A2 | PREPARATION OF ALPHA-KETOPIMELIC ACID | DSM IP ASSETS B.V. (NL) | 2011-03-17 | — | — | WO | disclosed |
| WO-2010104390-A2 | PREPARATION OF ALPHA-KETOPIMELIC ACID | DSM IP ASSETS B.V. (NL) | 2010-09-16 | — | — | WO | disclosed |
| US-7767204-B2 | Method and composition for protecting neuronal tissue from damage induced by elevated glutamate levels | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2010-08-03 | — | — | US | disclosed |
| US-20090304661-A1 | Method And Composition For Proctecting Neuronal Tissue From Damage Induced By Elevated Glutamate Levels | YEDA RESEARCH AND DEVELOPMENT CO. LTD. AT THE WEIZMANN INSTITUTE OF SCEINCE (IL) | 2009-12-10 | — | — | US | disclosed |
| US-20080233096-A1 | transaminase, dehydrogenase, decarboxylase, ligase as glutamate modifying enzymes and oxaloacetate, pyruvate, NAD+, NADP+, 2-oxohexanedioic acid, 2-oxo-3-sulfopropionate, 2-oxo-3-sulfinopropionic acid, 2-oxo-3-phenylpropionic acid co-factors to enhance brain to blood efflux | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2008-09-25 | — | — | US | disclosed |
| US-20080233099-A1 | Method and composition for protecting neuronal tissue from damage induced by elevated glutamate levels | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2008-09-25 | — | — | US | disclosed |
| US-7404951-B2 | Method and composition for protecting neuronal tissue from damage induced by elevated glutamate levels | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2008-07-29 | — | — | US | disclosed |
| US-20060024284-A1 | Method and composition for protecting neuronal tissue from damage induced by elevated glutamate levels | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2006-02-02 | — | — | US | disclosed |