Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | GRM8 | O00222 | 1/20 | 0.50 |
| ▸ | GRM6 | O15303 | 1/20 | 0.50 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.50 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.50 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.50 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.50 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.50 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.50 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.50 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.50 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.50 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.50 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.50 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.50 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL2020671 | 1.00 | GSR (0.67) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Lysine SCHEMBL1442876 | 0.92 | GSR (0.69) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Lysine SCHEMBL3457784 | 0.92 | GSR (0.69) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Lysine SCHEMBL28250523 | 0.91 | GSR (0.74) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Lysine SCHEMBL28250522 | 0.91 | GSR (0.74) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Lysine SCHEMBL8950852 | 0.91 | GSR (0.80) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Lysine SCHEMBL8950851 | 0.91 | GSR (0.80) | GSRCYP1A2GRM8GRM6GRIN2D | |
| (S)-2-Aminoadipic Acid SCHEMBL29106852 | 0.90 | GSR (0.57) | GSRCYP1A2GRM8GRM6GRIN2D | |
| (S)-2-Aminoadipic Acid SCHEMBL15845186 | 0.88 | GSR (0.80) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Lysine SCHEMBL8759022 | 0.88 | GSR (0.80) | GSRCYP1A2GRM8GRM6GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110158980-A1 | METHODS TO TREAT AND SCREEN FOR AGENTS TO TREAT OBESITY | TRUSTEES OF TUFTS COLLEGE (US) | 2011-06-30 | — | — | US | disclosed |
| WO-2010019434-A1 | METHODS TO TREAT AND SCREEN FOR AGENTS TO TREAT OBESITY | TRUSTEES OF TUFTS COLLEGE (US) | 2010-02-18 | — | — | WO | disclosed |