Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 3/20 | 0.38 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.34 |
| ▸ | RAPGEF4 | Q8WZA2 | 3/20 | 0.33 |
| ▸ | RAPGEF3 | O95398 | 4/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.32 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 2/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1626451 | 0.85 | AR (0.41) | ARSCN10ARAPGEF4RAPGEF3AKR1C3 | |
| SCHEMBL604108 | 0.82 | TSHR (0.50) | ARSCN10ATSHRALDH1A1S1PR1 | |
| SCHEMBL1626865 | 0.82 | SCN10A (0.36) | ARSCN10AAKR1C3AKR1C2CSNK1D | |
| SCHEMBL4573170 | 0.81 | AR (0.37) | ARSCN10ATSHRALDH1A1CYP2C9 | |
| SCHEMBL4573928 | 0.80 | RAPGEF4 (0.43) | ARRAPGEF4RAPGEF3 | |
| SCHEMBL530212 | 0.78 | ALDH1A1 (0.41) | RAPGEF4AKR1C3AKR1C2TSHRALDH1A1 | |
| SCHEMBL3951887 | 0.78 | ESR1 (0.40) | ARRAPGEF4AKR1C3AKR1C2TSHR | |
| SCHEMBL31499368 | 0.78 | ALDH1A1 (0.41) | RAPGEF4AKR1C3AKR1C2TSHRALDH1A1 | |
| SCHEMBL12987933 | 0.78 | AR (0.40) | ARSCN10AALDH1A1 | |
| SCHEMBL17157434 | 0.78 | SCN10A (0.34) | SCN10ACSNK1DCSNK1G2ALDH1A1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |