Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYCR1 | P32322 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | STK10 | O94804 | 1/20 | 0.35 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ACLY | P53396 | 2/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11212999 | 0.86 | SMN1; SMN2 (0.39) | PYCR1KDM4ETDP1TSHRGLA | |
| SCHEMBL11708277 | 0.81 | CA12 (0.48) | KDM4EGAAALDH1A1LMNAMAPT | |
| SCHEMBL21381810 | 0.80 | LMNA (0.47) | PYCR1KDM4ETDP1TSHRGLA | |
| SCHEMBL2814435 | 0.79 | KDM4E (0.50) | KDM4ETSHRGLASMN1; SMN2GAA | |
| SCHEMBL27939162 | 0.79 | NR3C2 (0.41) | KDM4EAR | |
| SCHEMBL3535344 | 0.79 | TRPV4 (0.45) | KDM4EALDH1A1MAPTAR | |
| SCHEMBL29114196 | 0.77 | LMNA (0.38) | PYCR1KDM4ETDP1TSHRGLA | |
| SCHEMBL14879832 | 0.77 | SMN1; SMN2 (0.38) | PYCR1KDM4ETDP1TSHRGLA | |
| SCHEMBL15300774 | 0.77 | LMNA (0.40) | PYCR1KDM4ETDP1TSHRGLA | |
| SCHEMBL30870662 | 0.77 | LMNA (0.40) | PYCR1KDM4ETDP1TSHRGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |