Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.58 |
| ▸ | HTR2C | P28335 | 5/20 | 0.56 |
| ▸ | HTR2B | P41595 | 3/20 | 0.56 |
| ▸ | HTR2A | P28223 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | KIT | P10721 | 1/20 | 0.48 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14230629 | 0.95 | SYK (0.58) | SYKHTR2CHTR2BTSHRPOLB | |
| SCHEMBL23339695 | 0.86 | HTR1B (0.48) | HTR2CHTR2BHTR2APOLBKDM4E | |
| SCHEMBL13791083 | 0.85 | SYK (0.59) | SYKHTR2CHTR2BHTR2ATSHR | |
| SCHEMBL12409038 | 0.85 | SYK (0.71) | SYKHTR2CHTR2BHTR2ATSHR | |
| SCHEMBL212928 | 0.84 | HTR2C (0.59) | SYKHTR2CHTR2BHTR2ATSHR | |
| SCHEMBL2424092 | 0.84 | SYK (0.58) | SYKHTR2CHTR2BHTR2ATSHR | |
| SCHEMBL18058380 | 0.82 | TSHR (0.75) | HTR2CHTR2BTSHRPOLBCYP2D6 | |
| SCHEMBL4477326 | 0.82 | LTA4H (0.62) | HTR2CHTR2BHTR2APOLBKDM4E | |
| SCHEMBL13803105 | 0.82 | SYK (0.55) | SYKHTR2CHTR2BHTR2ATSHR | |
| SCHEMBL4056455 | 0.82 | ALDH1A1 (0.59) | SYKHTR2CHTR2BHTR2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |