SCHEMBL4573448 — predicted protein targets

Predicted protein targets (top 7)

	gene	UniProt	supporting neighbours	confidence
▸	SUV39H2	Q9H5I1	2/20	0.48

▸	MAP4K4	O95819	1/20	0.48

▸	GPR119	Q8TDV5	2/20	0.46

▸	NR1H3	Q13133	12/20	0.44

▸	NR1H2	P55055	12/20	0.44

▸	MAPT	P10636	1/20	0.43

▸	HDAC1	Q13547	1/20	0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL4573160	0.92	SUV39H2 (0.47)	SUV39H2MAP4K4GPR119NR1H3NR1H2
SCHEMBL8117347	0.92	SUV39H2 (0.47)	SUV39H2MAP4K4GPR119NR1H3NR1H2
SCHEMBL8109925	0.89	SUV39H2 (0.48)	SUV39H2MAP4K4GPR119NR1H3NR1H2
SCHEMBL4573063	0.89	SUV39H2 (0.48)	SUV39H2MAP4K4GPR119NR1H3NR1H2
SCHEMBL4573114	0.87	GPR119 (0.51)	SUV39H2MAP4K4GPR119NR1H3NR1H2
SCHEMBL8116063	0.87	GPR119 (0.51)	SUV39H2MAP4K4GPR119NR1H3NR1H2
SCHEMBL17385131	0.86	NR1H3 (0.46)	SUV39H2MAP4K4GPR119NR1H3NR1H2
SCHEMBL19107119	0.85	NR1H3 (0.54)	SUV39H2MAP4K4GPR119NR1H3NR1H2
SCHEMBL4573558	0.84	SUV39H2 (0.49)	SUV39H2MAP4K4GPR119NR1H3NR1H2
SCHEMBL8109701	0.84	SUV39H2 (0.49)	SUV39H2MAP4K4GPR119NR1H3NR1H2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2009001127-A1	CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS	ASTRAZENECA AB (SE)	2008-12-31	—	—	WO	disclosed