Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.51 |
| ▸ | NR1H2 | P55055 | 7/20 | 0.49 |
| ▸ | NR1H3 | Q13133 | 6/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 2/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8116063 | 1.00 | GPR119 (0.51) | GPR119NR1H2NR1H3MAP4K4SUV39H2 | |
| SCHEMBL4585094 | 0.90 | GPR119 (0.50) | GPR119NR1H2NR1H3SUV39H2CHRM4 | |
| SCHEMBL4573448 | 0.87 | SUV39H2 (0.48) | GPR119NR1H2NR1H3MAP4K4SUV39H2 | |
| SCHEMBL31180987 | 0.85 | GPR119 (0.59) | GPR119NR1H2NR1H3MAP4K4CHRM2 | |
| SCHEMBL8109925 | 0.85 | SUV39H2 (0.48) | GPR119NR1H2NR1H3MAP4K4SUV39H2 | |
| SCHEMBL4573063 | 0.85 | SUV39H2 (0.48) | GPR119NR1H2NR1H3MAP4K4SUV39H2 | |
| SCHEMBL4573033 | 0.84 | GPR119 (0.54) | GPR119NR1H2NR1H3MAP4K4SUV39H2 | |
| SCHEMBL8113167 | 0.84 | GPR119 (0.54) | GPR119NR1H2NR1H3MAP4K4SUV39H2 | |
| SCHEMBL31181004 | 0.80 | GPR119 (0.60) | GPR119MAP4K4CHRM4CHRM2PDK1 | |
| SCHEMBL4573558 | 0.80 | SUV39H2 (0.49) | GPR119NR1H2NR1H3MAP4K4SUV39H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |