Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | GLS | O94925 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8130203 | 0.90 | PLA2G10 (0.35) | KDM4DNR1H2KDM4EPKMBRD4 | |
| SCHEMBL31588543 | 0.79 | NR1H2 (0.48) | NR1H2KDM4EPKMALDH1A1KMT2A | |
| SCHEMBL31189316 | 0.79 | NR1H2 (0.48) | NR1H2KDM4EPKMALDH1A1KMT2A | |
| SCHEMBL25957458 | 0.79 | NR1H2 (0.48) | NR1H2KDM4EPKMALDH1A1KMT2A | |
| SCHEMBL14086999 | 0.77 | GPR119 (0.42) | KDM4DNR1H2ALDH1A1 | |
| SCHEMBL1932287 | 0.77 | NR1H2 (0.41) | NR1H2BRD4CTSKALDH1A1KMT2A | |
| SCHEMBL6608848 | 0.75 | HPGD (0.53) | NR1H2KDM4EPKMMAPTHPGD | |
| SCHEMBL14146004 | 0.75 | GLS (0.39) | NR1H2KDM4EPKMHPGDGLS | |
| SCHEMBL18053194 | 0.75 | GLS (0.37) | KDM4DNR1H2ALDH1A1KMT2AMEN1 | |
| SCHEMBL2862919 | 0.75 | GLS (0.37) | NR1H2KDM4EPKMHPGDGLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008062013-A1 | PREPARATION OF 4-SUBSTITUTED 2-AMINO-BENZO[4,5]FURO [3,2-D]PYRIMIDINE DERIVATIVES | CELLZOME LIMITED (GB) | 2008-05-29 | — | — | WO | disclosed |
| EP-1925619-A1 | Preparation of 4-substituted 2-amino-benzo[4,5]furo[3,2-d]pyrimidine derivatives | Cellzome (UK) Ltd. (GB) | 2008-05-28 | — | — | EP | disclosed |