Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 2/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.49 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | AHR | P35869 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4574494 | 0.92 | EGFR (0.51) | INSRALKPI4KBMAPK1MAPT | |
| SCHEMBL4574615 | 0.89 | PI4KB (0.50) | PI4KBMAPK1MAPTAHRHTT | |
| SCHEMBL4892850 | 0.85 | MAPT (0.66) | PI4KBMAPK1MAPTAHRHTT | |
| SCHEMBL4931410 | 0.76 | MAPT (0.66) | INSRPI4KBMAPK1MAPTAHR | |
| SCHEMBL4890249 | 0.75 | CD38 (0.49) | PI4KBMAPK1MAPTAHRHTT | |
| SCHEMBL4935871 | 0.73 | RAF1 (0.64) | INSRPI4KBMAPK1MAPTAHR | |
| SCHEMBL4008515 | 0.72 | MAPT (0.80) | PI4KBMAPK1MAPTAHRHTT | |
| SCHEMBL4938676 | 0.72 | MAPT (0.60) | INSRPI4KBMAPK1MAPTAHR | |
| SCHEMBL4758836 | 0.72 | MAPT (0.60) | INSRPI4KBMAPK1MAPTAHR | |
| SCHEMBL4889676 | 0.72 | MAPK1 (0.48) | PI4KBMAPK1MAPTAHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008056149-A1 | QUINAZOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ARROW THERAPEUTICS LIMITED (GB) | 2008-05-15 | — | — | WO | claimed |
| WO-2008056149-A1 | QUINAZOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ARROW THERAPEUTICS LIMITED (GB) | 2008-05-15 | — | — | WO | disclosed |