Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 16/20 | 0.64 |
| ▸ | BRAF | P15056 | 16/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | AHR | P35869 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.61 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | KIF5B | P33176 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | INSR | P06213 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.51 |
| ▸ | CDK4 | P11802 | 1/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4931410 | 0.91 | MAPT (0.66) | RAF1BRAFMAPTMAPK1AHR | |
| SCHEMBL4938676 | 0.87 | MAPT (0.60) | RAF1BRAFMAPTMAPK1AHR | |
| SCHEMBL4758836 | 0.87 | MAPT (0.60) | RAF1BRAFMAPTMAPK1AHR | |
| SCHEMBL4008515 | 0.87 | MAPT (0.80) | RAF1BRAFMAPTMAPK1AHR | |
| SCHEMBL4889795 | 0.85 | MAPK1 (0.64) | RAF1BRAFMAPTMAPK1AHR | |
| SCHEMBL4940130 | 0.84 | KDR (0.62) | BRAFMAPTMAPK1AHRHTT | |
| SCHEMBL4937051 | 0.84 | KDR (0.62) | BRAFMAPTMAPK1AHRHTT | |
| SCHEMBL4789541 | 0.83 | MAPT (0.66) | RAF1BRAFMAPTMAPK1AHR | |
| SCHEMBL4890620 | 0.83 | EGFR (0.71) | MAPTMAPK1AHRHTTRET | |
| SCHEMBL4007152 | 0.82 | MAPK1 (0.72) | MAPTMAPK1AHRHTTPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080267914-A1 | Chemical Compounds | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080267914-A1 | Chemical Compounds | RNASEL, ZC3HAV1L, RNASEH1 | RAF1 744/4885BRAF 1306/4885MAPT 4645/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.