Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | AHR | P35869 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CD38 | P28907 | 1/20 | 0.43 |
| ▸ | PRKDC | P78527 | 6/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4573993 | 0.89 | INSR (0.49) | PI4KBMAPK1MAPTAHRHTT | |
| SCHEMBL4574494 | 0.87 | EGFR (0.51) | PI4KBMAPK1MAPTAHRHTT | |
| SCHEMBL4892850 | 0.87 | MAPT (0.66) | PI4KBMAPK1MAPTAHRHTT | |
| SCHEMBL4890249 | 0.86 | CD38 (0.49) | PI4KBMAPK1MAPTAHRHTT | |
| SCHEMBL4882141 | 0.82 | MAPT (0.57) | PI4KBMAPK1MAPTAHRHTT | |
| SCHEMBL4008515 | 0.74 | MAPT (0.80) | PI4KBMAPK1MAPTAHRHTT | |
| SCHEMBL4889676 | 0.74 | MAPK1 (0.48) | PI4KBMAPK1MAPTAHRHTT | |
| SCHEMBL4895102 | 0.72 | MAPT (0.63) | PI4KBMAPK1MAPTAHRHTT | |
| SCHEMBL15545775 | 0.72 | CYP1A2 (0.57) | MAPTHTTNPC1POLBRAB9A | |
| SCHEMBL4891700 | 0.72 | CLK4 (0.67) | PI4KBMAPK1MAPTAHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008056149-A1 | QUINAZOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ARROW THERAPEUTICS LIMITED (GB) | 2008-05-15 | — | — | WO | claimed |
| WO-2008056149-A1 | QUINAZOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ARROW THERAPEUTICS LIMITED (GB) | 2008-05-15 | — | — | WO | disclosed |