Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 17/20 | 0.61 |
| ▸ | HTR2A | P28223 | 17/20 | 0.61 |
| ▸ | HTR1A | P08908 | 16/20 | 0.61 |
| ▸ | FAAH | O00519 | 1/20 | 0.60 |
| ▸ | DRD3 | P35462 | 1/20 | 0.60 |
| ▸ | HTR2C | P28335 | 2/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.57 |
| ▸ | HRH1 | P35367 | 2/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4574186 | 0.99 | DRD2 (0.60) | DRD2HTR2AHTR1AFAAHDRD3 | |
| SCHEMBL4624803 | 0.89 | DRD2 (0.58) | DRD2HTR2AHTR1AFAAHDRD3 | |
| SCHEMBL4575061 | 0.85 | DRD2 (0.61) | DRD2HTR2AHTR1AFAAHDRD3 | |
| SCHEMBL29433199 | 0.85 | DRD2 (0.75) | DRD2HTR2AHTR1AHTR2CADRA1A | |
| SCHEMBL4589842 | 0.84 | HTR1A (0.51) | DRD2HTR2AHTR1AFAAHDRD3 | |
| SCHEMBL4574007 | 0.83 | DRD2 (0.61) | DRD2HTR2AHTR1AHTR2CADRA1A | |
| SCHEMBL294229 | 0.83 | DRD2 (0.66) | DRD2HTR2AHTR1ADRD3HTR2C | |
| SCHEMBL30176777 | 0.81 | DRD2 (0.67) | DRD2HTR2AHTR1AHTR2CADRA1A | |
| SCHEMBL293734 | 0.81 | DRD2 (0.67) | DRD2HTR2AHTR1AHTR2CADRA1A | |
| SCHEMBL4574005 | 0.81 | DRD2 (0.64) | DRD2HTR2AHTR1AHTR2CADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008047883-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENES FOR TREATMENT OF MENTAL DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-04-24 | — | — | WO | claimed |
| WO-2008047883-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENES FOR TREATMENT OF MENTAL DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-04-24 | — | — | WO | disclosed |