Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | JAK3 | P52333 | 2/20 | 0.44 |
| ▸ | MLNR | O43193 | 13/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2022959 | 0.80 | XIAP (0.40) | MLNRCYP3A4 | |
| SCHEMBL2925434 | 0.79 | LMNA (0.54) | GAAALDH1A1CHRM2 | |
| SCHEMBL14708215 | 0.78 | JAK2 (0.52) | JAK2JAK3GAAJAK1TYK2 | |
| SCHEMBL25640506 | 0.78 | TACR1 (0.39) | JAK2JAK3GAAJAK1TYK2 | |
| SCHEMBL20817868 | 0.78 | LMNA (0.62) | MLNRALDH1A1 | |
| SCHEMBL30616176 | 0.78 | LMNA (0.62) | MLNRALDH1A1 | |
| SCHEMBL13595851 | 0.77 | ACHE (0.61) | CYP2D6 | |
| SCHEMBL4590018 | 0.77 | XIAP (0.48) | MLNRCYP3A4 | |
| SCHEMBL4590022 | 0.77 | XIAP (0.48) | MLNRCYP3A4 | |
| SCHEMBL3172097 | 0.77 | KDM4E (0.55) | MLNRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008134035-A1 | ALPHA-UNSUBSTITUTED ARYLMETHYL PIPERAZINE PYRAZOLO[1,5-A] PYRIMIDINE AMIDE DERIVATIVES | PANACOS PHARMACEUTICALS, INC. (US) | 2008-11-06 | — | — | WO | disclosed |