Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | ACP3 | P15309 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10513016 | 0.81 | SIGMAR1 (0.59) | SIGMAR1IDO1THRBACP3POLB | |
| SCHEMBL9674688 | 0.79 | SIGMAR1 (0.52) | SIGMAR1IDO1THRBACP3POLB | |
| SCHEMBL4441100 | 0.78 | IDO1 (0.50) | SIGMAR1IDO1THRBACP3POLB | |
| SCHEMBL4190259 | 0.78 | IDO1 (0.50) | SIGMAR1IDO1THRBACP3POLB | |
| SCHEMBL4446397 | 0.78 | MEN1 (0.50) | SIGMAR1SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL4068553 | 0.77 | SMN1; SMN2 (0.55) | SIGMAR1IDO1THRBACP3POLB | |
| SCHEMBL29118392 | 0.77 | SIGMAR1 (0.48) | SIGMAR1IDO1THRBACP3POLB | |
| SCHEMBL1189292 | 0.75 | SIGMAR1 (0.68) | SIGMAR1IDO1THRBACP3POLB | |
| SCHEMBL1005593 | 0.75 | SIGMAR1 (0.68) | SIGMAR1IDO1THRBACP3POLB | |
| SCHEMBL1005591 | 0.75 | SIGMAR1 (0.68) | SIGMAR1IDO1THRBACP3POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2613630-A1 | HYDROGEN BOND FORMING FLUORO KETOLIDES FOR TREATING DISEASES | Cempra Pharmaceuticals, Inc. (US) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012034058-A1 | HYDROGEN BOND FORMING FLUORO KETOLIDES FOR TREATING DISEASES | CEMPRA PHARMACEUTICALS, INC. (US) | 2012-03-15 | — | — | WO | disclosed |