Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5566371 | 0.84 | KDM4E (0.36) | KDM4ESMN1; SMN2ALDH1A1MAPTHSD17B10 | |
| SCHEMBL4591398 | 0.80 | ATP4A (0.47) | SMN1; SMN2ALDH1A1MAPK1RAB9AHCRTR1 | |
| SCHEMBL4573822 | 0.78 | CA12 (0.48) | KDM4ESMN1; SMN2ALDH1A1HSD17B2MAPK1 | |
| SCHEMBL4169299 | 0.77 | SMN1; SMN2 (0.44) | KDM4ESMN1; SMN2ALDH1A1MAPK1RAB9A | |
| Alcohol SCHEMBL5566652 | 0.76 | CA12 (0.46) | KDM4ESMN1; SMN2ALDH1A1HSD17B2MAPK1 | |
| SCHEMBL8546144 | 0.73 | KDM4E (0.48) | KDM4ESMN1; SMN2ALDH1A1HSD17B2HPGD | |
| SCHEMBL12126791 | 0.71 | HSD17B2 (0.55) | KDM4ESMN1; SMN2ALDH1A1HSD17B2RAB9A | |
| SCHEMBL6580057 | 0.71 | HSD17B2 (0.67) | KDM4EALDH1A1HSD17B2TP53MAPT | |
| SCHEMBL5152746 | 0.71 | HSD17B2 (0.51) | KDM4EHSD17B2 | |
| SCHEMBL4737793 | 0.70 | KDM4E (0.41) | KDM4EALDH1A1HSD17B2RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008071766-A2 | SPIRO-INDENE SUBSTITUTED IMIDAZONAPHYTHYRIDINE AND PYRANOIMIDAZOPYRIDINE DERIVATIVES AS INHIBITORS OF GASTRIC ACID SECRETION | NYCOMED GMBH (DE) | 2008-06-19 | — | — | WO | disclosed |