Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | NAAA | Q02083 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | PPM1B | O75688 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1826045 | 0.95 | ALDH1A1 (0.40) | ALDH1A1ATMTSHRHPGDL3MBTL1 | |
| SCHEMBL8860789 | 0.95 | NAAA (0.41) | ALDH1A1TSHRMAPK1HCAR2NAAA | |
| SCHEMBL9579423 | 0.94 | NAAA (0.43) | TSHRMAPK1HCAR2NAAASMN1; SMN2 | |
| SCHEMBL7293847 | 0.90 | NAAA (0.40) | TSHRMAPK1NAAASMN1; SMN2EPHX2 | |
| SCHEMBL7286186 | 0.90 | PPM1B (0.41) | ALDH1A1HCAR2LMNAPPM1BPTPN1 | |
| SCHEMBL7296422 | 0.89 | NAAA (0.42) | TSHRMAPK1HCAR2NAAASMN1; SMN2 | |
| SCHEMBL6050484 | 0.85 | PPM1B (0.41) | ALDH1A1HCAR2NAAAPPM1BPTPN1 | |
| SCHEMBL1049438 | 0.82 | ALDH1A1 (0.39) | ALDH1A1PPM1BPTPN1 | |
| SCHEMBL234450 | 0.77 | ALDH1A1 (0.41) | ALDH1A1ATML3MBTL1PPM1BPTPN1 | |
| SCHEMBL1938997 | 0.76 | ALDH1A1 (0.38) | ALDH1A1ATMTSHRHPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008080937-A1 | 2-SUBSTITUTED PYRIMIDINES I IN THERAPY | BASF SE (DE) | 2008-07-10 | — | — | WO | disclosed |
| US-20080146593-A1 | Substituted 5-Phenyl Pyrimidines I In Therapy | BASF AKTIENGESELLSCHAFT (DE) | 2008-06-19 | — | — | US | disclosed |
| EP-1845991-A2 | SUBSTITUTED 5-PHENYL PYRIMIDINES I IN THERAPY | BASF AKTIENGESELLSCHAFT (DE) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006079556-A2 | SUBSTITUTED 5-PHENYL PYRIMIDINES I IN THERAPY | BASF AKTIENGESELLSCHAFT (DE) | 2006-08-03 | — | — | WO | disclosed |
| WO-1999052365-A1 | ANTICANCER AGENTS | ELI LILLY AND COMPANY (US) | 1999-10-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146593-A1 | Substituted 5-Phenyl Pyrimidines I In Therapy | NR1H2, NR1H3, NR1I2 | ALDH1A1 543/4885ATM 3160/4885TSHR 135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.