⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL491540 | 0.85 | — | — | |
| SCHEMBL1637718 | 0.81 | — | — | |
| SCHEMBL28183839 | 0.77 | — | — | |
| SCHEMBL28761348 | 0.77 | GABRA1 (0.37) | — | |
| SCHEMBL1636132 | 0.77 | HSD17B10 (0.33) | — | |
| SCHEMBL28331835 | 0.77 | GABRA1 (0.30) | — | |
| SCHEMBL28318557 | 0.74 | — | — | |
| SCHEMBL23581975 | 0.73 | ALDH1A1 (0.44) | — | |
| SCHEMBL18896 | 0.72 | — | — | |
| SCHEMBL4852858 | 0.72 | ALDH1A1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 515 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116178267-A | Chiral N-heterocyclic carbene nitrile oxide adduct organic catalyst and application thereof | 大连理工大学 | 2023-05-30 | — | — | CN | claimed |
| CN-114853795-A | Arylboron compound of conjugated olefin and preparation method and application thereof | 南京工业大学 | 2022-08-05 | — | — | CN | claimed |
| CN-110156622-B | Polysubstituted benzene derivative and synthetic method thereof | 上海大学 | 2022-07-29 | — | — | CN | claimed |
| CN-112851685-A | Polysubstituted furo-cycloheptatriene pyrrole derivative and preparation method thereof | 山东师范大学 | 2021-05-28 | — | — | CN | claimed |
| CN-112778324-A | Polysubstituted difuran cycloheptatrienamine derivative and preparation method thereof | 山东师范大学 | 2021-05-11 | — | — | CN | claimed |
| US-10441946-B2 | Linear alpha-olefin catalysts and preparation and use thereof | APALENE TECHNOLOGY CO., LTD. (HANGZHOU) (CN) | 2019-10-15 | — | — | US | claimed |
| CN-110156622-A | Multi substituted benzenes derivative and its synthetic method | 上海大学 | 2019-08-23 | — | — | CN | claimed |
| US-20180147571-A1 | NOVEL LINEAR ALPHA-OLEFIN CATALYSTS AND PREPARATION AND USE THEREOF | APALENE TECHNOLOGY CO., LTD. (JIAXING) (CN) | 2018-05-31 | — | — | US | claimed |
| EP-3022185-B1 | PESTICIDE COMPOUNDS | BASF SE (DE) | 2017-09-06 | — | — | EP | claimed |
| CN-104016990-B | A kind of Imidazopyrazines analog derivative and preparation method and application | SHANDONG UNIVERSITY (CN) | 2016-11-30 | — | — | CN | claimed |
| EP-0674624-B1 | PYRAZOLES HAVING CRF ANTAGONIST ACTIVITY | PFIZER (US) | 1999-01-20 | — | — | EP | claimed |
| WO-1998003508-A2 | SUBSTITUTED TRIAZOLOAZINE SULPHONAMIDES AND THEIR USE AS PLANT-TREATMENT AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1998-01-29 | — | — | WO | claimed |
| US-5712303-A | ANTIDEPRESSANTS | PFIZER INC. (US) | 1998-01-27 | — | — | US | claimed |
| US-5705646-A | Substituted pyrazoles as CRF antagonists | PFIZER INC. (US) | 1998-01-06 | — | — | US | claimed |
| CN-1149870-A | Substituted pyrazoles with corticotropin releasing factor antagonist activity | PFIZER (US) | 1997-05-14 | — | — | CN | claimed |
| EP-0764153-A1 | SUBSTITUTED PYRAZOLES HAVING CORTICOTROPIN-RELEASING FACTOR (CRF) ANTAGONIST ACTIVITY | PFIZER INC. (US) | 1997-03-26 | — | — | EP | claimed |
| WO-1995033727-A1 | SUBSTITUTED PYRAZOLES HAVING CORTICOTROPIN-RELEASING FACTOR (CRF) ANTAGONIST ACTIVITY | PFIZER INC. (US) | 1995-12-14 | — | — | WO | claimed |
| EP-0674631-A1 | SUBSTITUTED PYRAZOLES AS CRF ANTAGONISTS | PFIZER INC. (US) | 1995-10-04 | — | — | EP | claimed |
| CN-1093363-A | The pyrazoles that replaces | PFIZER (US) | 1994-10-12 | — | — | CN | claimed |
| WO-1994013661-A1 | SUBSTITUTED PYRAZOLES AS CRF ANTAGONISTS | PFIZER INC. (US) | 1994-06-23 | — | — | WO | claimed |