Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN7 | P35236 | 6/20 | 0.54 |
| ▸ | DUSP3 | P51452 | 6/20 | 0.54 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.54 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.51 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.50 |
| ▸ | CTSD | P07339 | 3/20 | 0.48 |
| ▸ | VNN1 | O95497 | 2/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4575400 | 0.88 | P2RX7 (0.51) | PTPN7DUSP3P2RX7RPS6KB1CTSD | |
| SCHEMBL15682779 | 0.87 | PTPN7 (0.53) | PTPN7DUSP3P2RX7RPS6KB1NR3C2 | |
| SCHEMBL16218921 | 0.82 | PTPN7 (0.57) | PTPN7DUSP3P2RX7RPS6KB1NR3C2 | |
| SCHEMBL17689391 | 0.82 | PTPN7 (0.57) | PTPN7DUSP3P2RX7RPS6KB1NR3C2 | |
| SCHEMBL14241834 | 0.79 | P2RX7 (0.60) | PTPN7DUSP3P2RX7 | |
| SCHEMBL15682816 | 0.79 | P2RX7 (0.54) | PTPN7DUSP3P2RX7RPS6KB1NR3C2 | |
| SCHEMBL16649581 | 0.79 | CNR2 (0.52) | — | |
| SCHEMBL12984838 | 0.76 | NR3C2 (0.52) | PTPN7DUSP3P2RX7RPS6KB1NR3C2 | |
| SCHEMBL4576236 | 0.76 | MTOR (0.54) | P2RX7RPS6KB1 | |
| SCHEMBL18415487 | 0.76 | TRPV1 (0.48) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673085-A4 | C-MET MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2008-12-10 | — | — | EP | disclosed |
| EP-1673085-A2 | C-MET MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005030140-A2 | C-MET MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2005-04-07 | — | — | WO | disclosed |