Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 4/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PMM2 | O15305 | 1/20 | 0.31 |
| ▸ | MPI | P34949 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10896862 | 0.89 | CYP3A4 (0.52) | CYP3A4TDP1ALDH1A1ATMPLAU | |
| SCHEMBL28049512 | 0.82 | TSHR (0.50) | CYP3A4TDP1ALDH1A1PLAUTSHR | |
| SCHEMBL28309346 | 0.81 | CYP3A4 (0.44) | CYP3A4TDP1ALDH1A1PLAUTSHR | |
| SCHEMBL14379109 | 0.81 | ALDH1A1 (0.60) | CYP3A4TDP1ALDH1A1TSHRMAPT | |
| SCHEMBL240574 | 0.78 | TDP1 (0.52) | CYP3A4TDP1ALDH1A1ATMTSHR | |
| SCHEMBL3496237 | 0.78 | TDP1 (0.41) | CYP3A4TDP1ALDH1A1ATMTSHR | |
| SCHEMBL27466789 | 0.77 | PLAU (0.45) | CYP3A4TDP1ALDH1A1ATMPLAU | |
| SCHEMBL27679749 | 0.76 | GRIA2 (0.38) | CYP3A4TDP1ALDH1A1ATMPLAU | |
| SCHEMBL2673604 | 0.76 | ALDH1A1 (0.33) | CYP3A4TDP1ALDH1A1ATMPLAU | |
| SCHEMBL1595410 | 0.75 | CYP3A4 (0.54) | CYP3A4TDP1ALDH1A1TSHRGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4470930-A | Preparation of nuclear chlorinated aromatic compounds | OCCIDENTAL CHEMICAL CORPORATION (US) | 1984-09-11 | — | — | US | claimed |
| US-7393849-B2 | Substituted sulfonamides and ureas useful for inhibiting kinase activity | AVENTIS PHARMACEUTICALS INC. (US) | 2008-07-01 | — | — | US | disclosed |
| US-7323457-B2 | Substituted sulfonamides and ureas useful for inhibiting kinase activity | AVENTIS PHARMACEUTICALS INC. (US) | 2008-01-29 | — | — | US | disclosed |
| US-20070208008-A1 | SUBSTITUTED SULFONAMIDES AND UREAS USEFUL FOR INHIBITING KINASE ACTIVITY | AVENTIS PHARMACEUTICALS INC. (US) | 2007-09-06 | — | — | US | disclosed |
| US-20070191347-A1 | SUBSTITUTED SULFONAMIDES AND UREAS USEFUL FOR INHIBITING KINASE ACTIVITY | AVENTIS PHARMACEUTICALS INC. | 2007-08-16 | — | — | US | disclosed |
| US-7223763-B2 | Substituted sulfonamides and ureas useful for inhibiting kinase activity | AVENTIS PHARMACEUTICALS INC. (US) | 2007-05-29 | — | — | US | disclosed |
| EP-1423373-B1 | SUBSTITUTED AMIDES, SULFONAMIDES AND UREAS USEFUL FOR INHIBITING KINASE ACTIVITY | AVENTIS PHARMA INC (US) | 2005-10-19 | — | — | EP | disclosed |
| US-20040204582-A1 | Substituted sulfonamides and ureas useful for inhibiting kinase activity | AVENTIS PHARMACEUTICALS INC. | 2004-10-14 | — | — | US | disclosed |
| US-6777577-B2 | ANTICANCER AGENTS; ANTIDIABETIC AGENTS, ANTICHOLESTEROL AGENTS, CARDIOVASCULAR DISORDERS, OSTEOPOROSIS | AVENTIS PHARMACEUTICALS INC. | 2004-08-17 | — | — | US | disclosed |
| EP-1423373-A2 | SUBSTITUTED AMIDES, SULFONAMIDES AND UREAS USEFUL FOR INHIBITING KINASE ACTIVITY | Aventis Pharmaceuticals, Inc. (US) | 2004-06-02 | — | — | EP | disclosed |
| US-20030087832-A1 | Substituted amides, sulfonamides and ureas useful for inhibiting kinase activity | AVENTIS PHARMACEUTICALS INC. | 2003-05-08 | — | — | US | disclosed |
| US-20030045480-A1 | Method of treating hyperresorptive bone disorders | ARIAD PHARMACEUTICALS, INC. | 2003-03-06 | — | — | US | disclosed |
| WO-2003006444-A2 | SUBSTITUTED AMIDES, SULFONAMIDES AND UREAS USEFUL FOR INHIBITING KINASE ACTIVITY | AVENTIS PHARMACEUTICALS INC. (US) | 2003-01-23 | — | — | WO | disclosed |
| US-4704483-A | FLUORINATION WITH POTASSIUM FLUORIDE | OCCIDENTAL CHEMICAL CORPORATION (US) | 1987-11-03 | — | — | US | disclosed |
| US-4582948-A | VAPOR PHASE CHLORO-DENITRATION REACTION | OCCIDENTAL CHEMICAL CORPORATION (US) | 1986-04-15 | — | — | US | disclosed |
| EP-0159388-A2 | Preparation of nuclear chlorinated compounds | OCCIDENTAL CHEMICAL CORPORATION (US) | 1985-10-30 | — | — | EP | disclosed |
| US-4470930-A | Preparation of nuclear chlorinated aromatic compounds | OCCIDENTAL CHEMICAL CORPORATION (US) | 1984-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070208008-A1 | SUBSTITUTED SULFONAMIDES AND UREAS USEFUL FOR INHIBITING KINASE ACTIVITY | CHUK, SRC, DSTYK | CYP3A4 2665/4885TDP1 2093/4885ALDH1A1 4416/4885 |
| US-20040204582-A1 | Substituted sulfonamides and ureas useful for inhibiting kinase activity | CHUK, SRC, DSTYK | CYP3A4 2583/4885TDP1 1998/4885ALDH1A1 4315/4885 |
| US-20030045480-A1 | Method of treating hyperresorptive bone disorders | SRC, GRB2, ACP1 | CYP3A4 4718/4885TDP1 4172/4885ALDH1A1 4773/4885 |
| US-20070191347-A1 | SUBSTITUTED SULFONAMIDES AND UREAS USEFUL FOR INHIBITING KINASE ACTIVITY | CHUK, SRC, DSTYK | CYP3A4 2665/4885TDP1 2093/4885ALDH1A1 4416/4885 |
| US-20030087832-A1 | Substituted amides, sulfonamides and ureas useful for inhibiting kinase activity | SRC, CHUK, DSTYK | CYP3A4 2690/4885TDP1 1987/4885ALDH1A1 4274/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.