SCHEMBL28309346

SCHEMBL28309346

O=C=Nc1cccc(Cl)c1[N+](=O)[O-]

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.44
GRIN2D O15399 1/20 0.40
GRIN3B O60391 1/20 0.40
GRIN1 Q05586 1/20 0.40
GRIN2A Q12879 1/20 0.40
GRIN2B Q13224 1/20 0.40
GRIN2C Q14957 1/20 0.40
GRIN3A Q8TCU5 1/20 0.40
ALDH1A1 P00352 5/20 0.37
TSHR P16473 3/20 0.37
TDP1 Q9NUW8 3/20 0.37
HSP90AA1 P07900 2/20 0.36
PMM2 O15305 1/20 0.36
MPI P34949 1/20 0.36
KDM4E B2RXH2 1/20 0.36
MEN1 O00255 1/20 0.36
LMNA P02545 1/20 0.36
POLB P06746 1/20 0.36
MAPT P10636 1/20 0.36
HTT P42858 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10896862 0.87 CYP3A4 (0.52) CYP3A4ALDH1A1TSHRTDP1HSP90AA1
SCHEMBL4575697 0.81 CYP3A4 (0.46) CYP3A4ALDH1A1TSHRTDP1PMM2
SCHEMBL28049512 0.81 TSHR (0.50) CYP3A4ALDH1A1TSHRTDP1MEN1
SCHEMBL14379109 0.79 ALDH1A1 (0.60) CYP3A4ALDH1A1TSHRTDP1MEN1
SCHEMBL11114667 0.79 GRIN2D (0.42) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL28069553 0.78 PLAU (0.56) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL670917 0.77 TSHR (0.58) CYP3A4GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL6172008 0.77 ALDH1A1 (0.41) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL10974014 0.76 PLAU (0.45) CYP3A4ALDH1A1TSHRTDP1KDM4E
SCHEMBL29011317 0.74 CYP3A4 (0.37) CYP3A4ALDH1A1TDP1PMM2MPI

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110068616-A The normal-phase chromatography analysis method of chloro- 2 nitrophenyl isocyanate of 4- and its reaction solution 联化科技股份有限公司 2019-07-30 CN claimed
CN-110068616-A The normal-phase chromatography analysis method of chloro- 2 nitrophenyl isocyanate of 4- and its reaction solution 联化科技股份有限公司 2019-07-30 CN disclosed
CN-110068616-A The normal-phase chromatography analysis method of chloro- 2 nitrophenyl isocyanate of 4- and its reaction solution 联化科技股份有限公司 2019-07-30 CN disclosed
CN-110068616-A The normal-phase chromatography analysis method of chloro- 2 nitrophenyl isocyanate of 4- and its reaction solution 联化科技股份有限公司 2019-07-30 CN disclosed