SCHEMBL457571

SCHEMBL457571

O=C1C(=O)C(=O)C(O)C1=O

nearest known ligand 0.35

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.31
MEN1 O00255 1/20 0.31
ALDH1A1 P00352 1/20 0.31
MAPT P10636 1/20 0.31
ALOX15 P16050 1/20 0.31
ALOX12 P18054 1/20 0.31
BLM P54132 1/20 0.31
KMT2A Q03164 1/20 0.31
TDP1 Q9NUW8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14441612 0.75 KDM4E (0.31) KDM4EMEN1ALDH1A1MAPTALOX15
SCHEMBL18677022 0.71 MAPT (0.33) KDM4EMAPT
SCHEMBL19052344 0.70 KDM4E (0.37) KDM4EMEN1ALDH1A1MAPTALOX15
SCHEMBL15746982 0.67
SCHEMBL6300746 0.67 KDM4E (0.31) KDM4EMEN1ALDH1A1MAPTALOX15
SCHEMBL20827851 0.67
SCHEMBL17085510 0.64
SCHEMBL649183 0.64
SCHEMBL10344203 0.63 MEN1 (0.55) KDM4EMEN1ALDH1A1MAPTALOX15
SCHEMBL1906786 0.62

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4167938-B1 BIODEGRADABLE UV ABSORBERS BASF SE (DE) 2025-08-27 EP disclosed
WO-2025081381-A1 NANOPARTICLES CAPABLE OF REALIZING CONTROLLED RELEASE OF CARBON MONOXIDE, AND PREPARATION METHOD THEREFOR AND USE THEREOF 中国科学院深圳先进技术研究院 2025-04-24 WO disclosed
CN-117414347-A Nanoparticle capable of controllably releasing carbon monoxide and preparation method and application thereof 中国科学院深圳先进技术研究院 2024-01-19 CN disclosed
US-20230293411-A1 BIODEGRADABLE UV ABSORBERS BASF SE (DE) 2023-09-21 US disclosed
EP-4167938-A1 BIODEGRADABLE UV ABSORBERS BASF SE (DE) 2023-04-26 EP disclosed
CN-115916143-A Biodegradable UV absorbers 巴斯夫欧洲公司 2023-04-04 CN disclosed
EP-3479863-B1 COMPOSITIONS, METHODS AND ARTICLES CONCERNING PHARMACEUTICAL NITRIC OXIDE AND CONTROLLED PATIENT DELIVERY SYSTEMS THEREOF MALLINCKRODT PHARMACEUTICALS IRELAND LTD (IE) 2021-11-24 EP disclosed
EP-3479863-A1 COMPOSITIONS, METHODS AND ARTICLES CONCERNING PHARMACEUTICAL NITRIC OXIDE AND CONTROLLED PATIENT DELIVERY SYSTEMS THEREOF INO Therapeutics LLC (US) 2019-05-08 EP disclosed
EP-2613839-B1 COMPOSITIONS, METHODS AND ARTICLES CONCERNING PHARMACEUTICAL NITRIC OXIDE AND CONTROLLED PATIENT DELIVERY SYSTEMS THEREOF INO THERAPEUTICS LLC (US) 2018-12-12 EP disclosed
US-9353092-B2 Synthesis and use of croconaine compounds UNIVERSITY OF NOTRE DAME DU LAC (US) 2016-05-31 US disclosed
US-20150005501-A1 SYNTHESIS AND USE OF CROCONAINE COMPOUNDS UNIVERSITY OF NOTRE DAME DU LAC (US) 2015-01-01 US disclosed
EP-2613839-A1 COMPOSITIONS, METHODS AND ARTICLES CONCERNING PHARMACEUTICAL NITRIC OXIDE AND CONTROLLED PATIENT DELIVERY SYSTEMS THEREOF Ikaria, Inc. (US) 2013-07-17 EP disclosed
WO-2012034089-A1 COMPOSITIONS, METHODS AND ARTICLES CONCERNING PHARMACEUTICAL NITRIC OXIDE AND CONTROLLED PATIENT DELIVERY SYSTEMS THEREOF IKARIA, INC. (US) 2012-03-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150005501-A1 SYNTHESIS AND USE OF CROCONAINE COMPOUNDS AADAT, CROCC, TNNT2 KDM4E 696/4885MEN1 4133/4885ALDH1A1 287/4885
US-20230293411-A1 BIODEGRADABLE UV ABSORBERS ERCC4, ERCC1, UNG KDM4E 2578/4885MEN1 1093/4885ALDH1A1 65/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.