Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 12/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 2/20 | 0.49 |
| ▸ | IDO1 | P14902 | 2/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5723612 | 0.82 | P2RX7 (0.57) | P2RX7EPHX2HDAC3HDAC1HDAC2 | |
| SCHEMBL4576032 | 0.80 | EPHX2 (0.55) | P2RX7EPHX2HDAC3HDAC1HDAC2 | |
| SCHEMBL16538118 | 0.79 | P2RX7 (0.57) | P2RX7EPHX2HDAC3HDAC1HDAC2 | |
| SCHEMBL6355300 | 0.78 | EPHX2 (0.55) | P2RX7EPHX2HDAC3HDAC1HDAC2 | |
| SCHEMBL4576018 | 0.77 | P2RX7 (0.54) | P2RX7EPHX2 | |
| SCHEMBL6355022 | 0.76 | EPHX2 (0.53) | P2RX7EPHX2HDAC3HDAC1HDAC2 | |
| SCHEMBL16972742 | 0.76 | HDAC3 (0.55) | P2RX7EPHX2HDAC3HDAC1HDAC2 | |
| SCHEMBL13068534 | 0.74 | HDAC3 (0.57) | P2RX7EPHX2HDAC3HDAC1HDAC2 | |
| SCHEMBL5723611 | 0.74 | IDO1 (0.53) | P2RX7EPHX2HDAC3HDAC1HDAC2 | |
| SCHEMBL4575400 | 0.73 | P2RX7 (0.51) | P2RX7PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673085-A4 | C-MET MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2008-12-10 | — | — | EP | claimed |
| EP-1673085-A2 | C-MET MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2006-06-28 | — | — | EP | claimed |
| WO-2005030140-A2 | C-MET MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2005-04-07 | — | — | WO | claimed |
| EP-1673085-A4 | C-MET MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2008-12-10 | — | — | EP | disclosed |
| EP-1673085-A2 | C-MET MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005030140-A2 | C-MET MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2005-04-07 | — | — | WO | disclosed |