Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 13/20 | 0.54 |
| ▸ | CD38 | P28907 | 1/20 | 0.47 |
| ▸ | CFD | P00746 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | FPR3 | P25089 | 1/20 | 0.41 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30152460 | 0.87 | P2RX7 (0.55) | P2RX7CD38EPHX2FPR3FPR2 | |
| SCHEMBL23195275 | 0.87 | P2RX7 (0.55) | P2RX7CD38EPHX2FPR3FPR2 | |
| SCHEMBL4576032 | 0.86 | EPHX2 (0.55) | P2RX7EPHX2 | |
| SCHEMBL3294867 | 0.83 | P2RX7 (0.57) | P2RX7CD38EPHX2FPR3FPR2 | |
| SCHEMBL30252237 | 0.82 | P2RX7 (0.56) | P2RX7CD38EPHX2FPR3FPR2 | |
| SCHEMBL4576232 | 0.77 | P2RX7 (0.55) | P2RX7EPHX2 | |
| SCHEMBL31645651 | 0.76 | P2RX7 (0.47) | P2RX7CD38 | |
| SCHEMBL27913635 | 0.75 | KMT2A (0.56) | P2RX7EPHX2 | |
| SCHEMBL13568952 | 0.73 | P2RX7 (0.43) | P2RX7CD38CFDEPHX2FPR3 | |
| SCHEMBL4586644 | 0.73 | EPHX2 (0.57) | P2RX7CD38EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673085-A4 | C-MET MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2008-12-10 | — | — | EP | claimed |
| EP-1673085-A2 | C-MET MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2006-06-28 | — | — | EP | claimed |
| WO-2005030140-A2 | C-MET MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2005-04-07 | — | — | WO | claimed |