⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4576539 | 0.79 | ALDH1A1 (0.37) | — | |
| SCHEMBL27819493 | 0.71 | — | — | |
| SCHEMBL18643508 | 0.70 | — | — | |
| SCHEMBL25442 | 0.69 | — | — | |
| SCHEMBL6408885 | 0.69 | — | — | |
| SCHEMBL8585245 | 0.69 | — | — | |
| Acetone SCHEMBL226043 | 0.66 | LMNA (0.55) | — | |
| Ammonia Solution, Strong SCHEMBL6341151 | 0.66 | — | — | |
| Hydrogen Peroxide SCHEMBL8626398 | 0.66 | ALDH1A1 (0.50) | — | |
| SCHEMBL2991355 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080311099-A1 | Pyridoxal-5-Phosphate and Related Compounds in Combination With Therapeutic Cardiovascular Compounds for Treating Angina | MEDICURE INTERNATIONAL INC. | 2008-12-18 | — | — | US | disclosed |
| US-7442689-B2 | Cardioprotective phosphonates and malonates | MEDICURE INTERNATIONAL INC. (BB) | 2008-10-28 | — | — | US | disclosed |
| US-20070167411-A1 | Compositions for treating angina | MEDICURE INTERNATIONAL INC. (BB) | 2007-07-19 | — | — | US | disclosed |
| US-20070032456-A1 | Modulation of cell death | MEDICURE INC. (CA) | 2007-02-08 | — | — | US | disclosed |
| US-7105673-B2 | Cardioprotective phosphonates and malonates | MEDICURE INTERNATIONAL INC. (BB) | 2006-09-12 | — | — | US | disclosed |
| EP-1610783-A2 | MODULATION OF CELL DEATH | Medicure Inc. (CA) | 2006-01-04 | — | — | EP | disclosed |
| EP-1608379-A1 | COMPOSITIONS FOR TREATING ANGINA | Medicure Inc. (CA) | 2005-12-28 | — | — | EP | disclosed |
| EP-1531157-A1 | Cardioprotective phosphonates | Medicure International Inc. (BB) | 2005-05-18 | — | — | EP | disclosed |
| EP-1268498-B1 | CARDIOPROTECTIVE PHOSPHONATES | MEDICURE INT INC (BB) | 2005-04-13 | — | — | EP | disclosed |
| US-6867215-B2 | Cardioprotective phosphonates and malonates | MEDICURE INTERNATIONAL INC. (BB) | 2005-03-15 | — | — | US | disclosed |
| US-20030120074-A1 | Cardioprotective phosphonates and malonates | MEDICURE INTERNATIONAL INC. (BB) | 2003-06-26 | — | — | US | disclosed |
| US-20030114678-A1 | Cardioprotective phosphonates and malonates | MEDICURE INTERNATIONAL INC. (BB) | 2003-06-19 | — | — | US | disclosed |
| US-20030114424-A1 | Treatment of cerebrovascular disease | MEDICURE INTERNATIONAL INC. (BB) | 2003-06-19 | — | — | US | disclosed |
| US-20030114677-A1 | Cardioprotective phosphonates and malonates | MEDICURE INTERNATIONAL INC. (BB) | 2003-06-19 | — | — | US | disclosed |
| EP-1278526-A2 | TREATMENT OF CEREBROVASCULAR DISEASE | Medicure International Inc. (BB) | 2003-01-29 | — | — | EP | disclosed |
| EP-1268498-A1 | CARDIOPROTECTIVE PHOSPHONATES AND MALONATES | Medicure International Inc. (BB) | 2003-01-02 | — | — | EP | disclosed |
| US-20020010158-A1 | Cardioprotective phosphonates and malonates | MEDICURE INTERNATIONAL INC. (CA) | 2002-01-24 | — | — | US | disclosed |
| US-20010056081-A1 | Treatment of cerebrovascular disease | MEDICURE INTERNATIONAL INC. (CA) | 2001-12-27 | — | — | US | disclosed |
| WO-2001072309-A2 | TREATMENT OF CEREBROVASCULAR DISEASE | MEDICURE INTERNATIONAL INC. (US) | 2001-10-04 | — | — | WO | disclosed |
| WO-2001064692-A1 | CARDIOPROTECTIVE PHOSPHONATES AND MALONATES | MEDICURE INTERNATIONAL INC. (BB) | 2001-09-07 | — | — | WO | disclosed |