Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.35 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL23783571 | 0.98 | KDM4E (0.37) | GLRA1SLC6A9OR51E2TDP1GAA | |
| SCHEMBL6116105 | 0.93 | — | — | |
| SCHEMBL44143 | 0.93 | — | — | |
| Hydrochloric Acid SCHEMBL336665 | 0.90 | KDM4E (0.38) | GLRA1SLC6A9OR51E2TDP1GAA | |
| Ammonia Solution, Strong SCHEMBL20241550 | 0.90 | TDP1 (0.36) | GLRA1SLC6A9OR51E2TDP1GAA | |
| SCHEMBL28278850 | 0.90 | TDP1 (0.36) | GLRA1SLC6A9OR51E2TDP1GAA | |
| Hydrochloric Acid SCHEMBL14659623 | 0.88 | TDP1 (0.35) | GLRA1SLC6A9OR51E2TDP1GAA | |
| Ethylamine SCHEMBL7474222 | 0.88 | TDP1 (0.35) | GLRA1SLC6A9OR51E2TDP1KDM4E | |
| SCHEMBL9725893 | 0.86 | TDP1 (0.34) | TDP1KDM4EDGAT1MAOAMAOB | |
| SCHEMBL1225343 | 0.85 | TDP1 (0.35) | TDP1GAAKDM4EDGAT1MGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111432844-B | PSMA-targeting amanitine conjugates | 海德堡医药研究有限责任公司 | 2023-10-27 | — | — | CN | disclosed |
| WO-2023075435-A1 | COMPOSITION FOR DETECTING OR MEASURING ANALYTE | 주식회사 베르티스 | 2023-05-04 | — | — | WO | disclosed |
| EP-3684416-B1 | PSMA-TARGETING AMANITIN CONJUGATES | HEIDELBERG PHARMA RES GMBH (DE) | 2023-03-15 | — | — | EP | disclosed |
| US-11583569-B2 | PSMA-targeting amanitin conjugates | HEIDELBERG PHARMA RESEARCH GMBH (DE) | 2023-02-21 | — | — | US | disclosed |
| US-20220283131-A1 | COMPOSITION FOR DETECTING OR MEASURING ANALYTES | BERTIS CO., LTD. (KR) | 2022-09-08 | — | — | US | disclosed |
| CN-109651224-B | Fluorescent protein cross-linking agent and preparation method thereof | 苏州昊帆生物股份有限公司 | 2022-05-10 | — | — | CN | disclosed |
| WO-2022050529-A1 | COMPOSITION FOR DETECTING OR MEASURING ANALYTE | ㈜베르티스 | 2022-03-10 | — | — | WO | disclosed |
| US-20200345807-A1 | PSMA-TARGETING AMANITIN CONJUGATES | HEIDELBERG PHARMA RESEARCH GMBH (DE) | 2020-11-05 | — | — | US | disclosed |
| EP-3684416-A1 | PSMA-TARGETING AMANITIN CONJUGATES | Heidelberg Pharma Research GmbH (DE) | 2020-07-29 | — | — | EP | disclosed |
| CN-111432844-A | Amanitine conjugates targeting PSMA | 海德堡医药研究有限责任公司 | 2020-07-17 | — | — | CN | disclosed |
| WO-2019057964-A1 | PSMA-TARGETING AMANITIN CONJUGATES | HEIDELBERG PHARMA RESEARCH GMBH (DE) | 2019-03-28 | — | — | WO | disclosed |
| CN-102391140-B | Preparation method of N-(2- indanyl) amino acid alkyl ester | HUNAN FANGSHENG PHARMACEUTICAL CO LTD | 2014-08-06 | — | — | CN | disclosed |
| CN-102391140-A | Preparation method of N-(2- indanyl) amino acid alkyl ester | HUNAN FANGSHENG PHARMACEUTICAL CO LTD | 2012-03-28 | — | — | CN | disclosed |
| US-20080269240-A1 | Novel Adenine Compound | Dainippon Sumitomo Pharma Co., Ltd. a corporation of Japan (JP) | 2008-10-30 | — | — | US | disclosed |
| EP-1939199-A1 | NOVEL ADENINE COMPOUND | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2008-07-02 | — | — | EP | disclosed |
| US-6359113-B1 | USING FUSED RING SYSTEM CONTAINING AT LEAST 4 AROMATIC RINGS, AND GROUP CONTAINING AT LEAST ONE CARBON ATOM WHICH IS CAPABLE OF BONDING TO A GROUP TO BE PROTECTED; SYNTHESIS, SEPARATION | RHODIA CHIMIE (FR) | 2002-03-19 | — | — | US | disclosed |
| US-5869605-A | Protected compound comprising a protective group removably attached to a compound to be protected | RHONE-POULENCCHIMIE (FR) | 1999-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269240-A1 | Novel Adenine Compound | ADORA1, ADORA2A, ADORA3 | GLRA1 1438/4885SLC6A9 912/4885OR51E2 3637/4885 |
| US-20200345807-A1 | PSMA-TARGETING AMANITIN CONJUGATES | FOLH1, ANPEP, PSMA6 | GLRA1 2839/4885SLC6A9 4000/4885OR51E2 1552/4885 |
| US-11583569-B2 | PSMA-targeting amanitin conjugates | FOLH1, ANPEP, PSMA6 | GLRA1 2839/4885SLC6A9 4000/4885OR51E2 1552/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.