Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.55 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7248629 | 0.84 | L3MBTL1 (0.62) | L3MBTL1OPRM1KCNH2HRH3 | |
| SCHEMBL8817072 | 0.83 | KCNH2 (0.61) | OPRM1KCNH2HRH3GRIN1GRIN2B | |
| Hydrochloric Acid SCHEMBL4577195 | 0.83 | KCNH2 (0.65) | OPRM1KCNH2HRH3GRIN1GRIN2B | |
| SCHEMBL10735474 | 0.81 | GRIN2B (0.73) | OPRM1KCNH2HRH3GRIN1GRIN2B | |
| SCHEMBL10734713 | 0.80 | CYP2C9 (0.65) | OPRM1KCNH2HRH3ALDH1A1GRIN1 | |
| SCHEMBL10733415 | 0.80 | GRIN2B (0.71) | KCNH2HRH3GRIN1GRIN2B | |
| SCHEMBL28597356 | 0.79 | GRIN1 (0.67) | KCNH2HRH3GRIN1GRIN2B | |
| SCHEMBL10735413 | 0.79 | GRIN2B (0.63) | OPRM1KCNH2HRH3GRIN1GRIN2B | |
| SCHEMBL10729114 | 0.79 | GRIN2B (0.69) | OPRM1KCNH2HRH3GRIN1GRIN2B | |
| SCHEMBL3313145 | 0.78 | ALDH1A1 (0.57) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7435744-B2 | Piperidine derivatives as NMDA receptor antagonists | GEDEON RICHTER VEGYESZETI GYAR RT (HU) | 2008-10-14 | — | — | US | disclosed |
| US-20040157886-A1 | Piperdine derivatives as NMDA receptor antagonists | UCB Biopharma SRL (BE) | 2004-08-12 | — | — | US | disclosed |
| EP-1409477-A1 | PIPERIDINE DERIVATIVES AS NMDA RECEPTOR ANTAGONISTS | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 2004-04-21 | — | — | EP | disclosed |
| WO-2003010159-A1 | PIPERIDINE DERIVATIVES AS NMDA RECEPTOR ANTAGONISTS | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 2003-02-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040157886-A1 | Piperdine derivatives as NMDA receptor antagonists | GRIN1, GRIN2D, GRIN2C | L3MBTL1 4145/4885OPRM1 8/4885KCNH2 65/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.