Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10895522 | 0.88 | KDM4E (0.46) | ALDH1A1HSD17B10KDM4EHIF1ATDP1 | |
| SCHEMBL4458686 | 0.86 | ALDH1A1 (0.46) | ALDH1A1HSD17B10KDM4EHIF1ATDP1 | |
| SCHEMBL9340040 | 0.82 | ALDH1A1 (0.53) | ALDH1A1HSD17B10KDM4EHIF1ATDP1 | |
| SCHEMBL25665243 | 0.82 | ALDH1A1 (0.53) | ALDH1A1HSD17B10KDM4EHIF1ATDP1 | |
| SCHEMBL30852342 | 0.82 | ALDH1A1 (0.53) | ALDH1A1HSD17B10KDM4EHIF1ATDP1 | |
| SCHEMBL30852281 | 0.81 | ALDH1A1 (0.59) | ALDH1A1HSD17B10KDM4EHIF1ATDP1 | |
| Kynurenine SCHEMBL2181581 | 0.78 | KDM4E (0.64) | ALDH1A1HSD17B10KDM4EHIF1ATDP1 | |
| Kynurenine SCHEMBL288988 | 0.78 | KDM4E (0.64) | ALDH1A1HSD17B10KDM4EHIF1ATDP1 | |
| L-Kynurenine SCHEMBL13969610 | 0.78 | KDM4E (0.64) | ALDH1A1HSD17B10KDM4EHIF1ATDP1 | |
| SCHEMBL247554 | 0.78 | KDM4E (0.47) | ALDH1A1HSD17B10KDM4EHIF1ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1311299-A4 | METHOD FOR THE IDENTIFICATION OF AGENTS THAT INHIBIT OR PROMOTE CATARACTS AND USES THEREOF | GEN HOSPITAL CORP (US) | 2008-01-02 | — | — | EP | disclosed |
| US-7166472-B2 | Method for the identification of agents that inhibit or promote cataracts and uses thereof | THE GENERAL HOSPITAL CORPORATION (US) | 2007-01-23 | — | — | US | disclosed |
| US-20050084918-A1 | Method for the identification of agents that inhibit or promote cataracts and uses thereof | BUSH ASHLEY I (US) | 2005-04-21 | — | — | US | disclosed |
| EP-1311299-A1 | METHOD FOR THE IDENTIFICATION OF AGENTS THAT INHIBIT OR PROMOTE CATARACTS AND USES THEREOF | THE GENERAL HOSPITAL CORPORATION (US) | 2003-05-21 | — | — | EP | disclosed |
| WO-2002015942-A1 | METHOD FOR THE IDENTIFICATION OF AGENTS THAT INHIBIT OR PROMOTE CATARACTS AND USES THEREOF | THE GENERAL HOSPITAL CORPORATION (US) | 2002-02-28 | — | — | WO | disclosed |