Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of O-Tolylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.68 |
| ▸ | CD44 | P16070 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA6 | P23280 | 1/20 | 0.43 |
| ▸ | CA5A | P35218 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| O-Tolylamine SCHEMBL27656306 | 0.98 | CYP3A4 (0.65) | CYP3A4TDP1CD44GAACA12 | |
| O-Tolylamine SCHEMBL30505312 | 0.93 | CYP3A4 (0.65) | CYP3A4TDP1CD44GAACA12 | |
| O-Tolylamine SCHEMBL4537950 | 0.93 | CYP3A4 (0.65) | CYP3A4TDP1CD44GAACA12 | |
| O-Tolylamine SCHEMBL28417578 | 0.86 | TSHR (0.61) | CYP3A4TDP1CD44CA12CA1 | |
| O-Tolylamine SCHEMBL5161740 | 0.86 | CYP3A4 (0.56) | CYP3A4TDP1CD44GAACA12 | |
| O-Tolylamine SCHEMBL31145800 | 0.84 | — | — | |
| O-Tolylamine SCHEMBL15789 | 0.84 | — | — | |
| O-Tolylamine SCHEMBL9613766 | 0.84 | CYP3A4 (0.94) | CYP3A4TDP1CD44GAACA1 | |
| O-Tolylamine SCHEMBL8469060 | 0.84 | CYP3A4 (0.94) | CYP3A4TDP1CD44GAACA1 | |
| O-Tolylamine SCHEMBL29441724 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 90 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250136537-A1 | SYSTEM AND PROCESS FOR CONTINUOUS PREPARATION OF meta-CRESOL BY NOx | DEEPAK NITRITE LIMITED (IN) | 2025-05-01 | — | — | US | claimed |
| CN-116621712-A | Continuous nitration preparation method of 2-amino-4-nitrotoluene microreactor | 武汉工程大学 | 2023-08-22 | — | — | CN | claimed |
| WO-2023047194-A1 | SYSTEM AND PROCESS FOR CONTINUOUS PREPARATION OF meta-CRESOL BY NOx | DEEPAK NITRITE LIMITED (IN) | 2023-03-30 | — | — | WO | claimed |
| CN-113121360-A | Preparation method of scarlet base G | 青岛海湾精细化工有限公司 | 2021-07-16 | — | — | CN | claimed |
| CN-116621712-B | Continuous nitration preparation method of 2-amino-4-nitrotoluene microreactor | 武汉工程大学 | 2025-08-22 | — | — | CN | disclosed |
| CN-119751349-A | Method for continuously synthesizing 8-methylquinoline | 江苏优士化学有限公司 | 2025-04-04 | — | — | CN | disclosed |
| CN-116621712-A | Continuous nitration preparation method of 2-amino-4-nitrotoluene microreactor | 武汉工程大学 | 2023-08-22 | — | — | CN | disclosed |
| CN-116621712-A | Continuous nitration preparation method of 2-amino-4-nitrotoluene microreactor | 武汉工程大学 | 2023-08-22 | — | — | CN | disclosed |
| WO-2023047194-A1 | SYSTEM AND PROCESS FOR CONTINUOUS PREPARATION OF meta-CRESOL BY NOx | DEEPAK NITRITE LIMITED (IN) | 2023-03-30 | — | — | WO | disclosed |
| CN-114908136-A | Preparation process and use of high-activity bone glycopeptide composite | 中国农业科学院农产品加工研究所 | 2022-08-16 | — | — | CN | disclosed |
| CN-113121360-A | Preparation method of scarlet base G | 青岛海湾精细化工有限公司 | 2021-07-16 | — | — | CN | disclosed |
| CN-101941890-B | Method and device for preparing metacresol | JIANGSU HUAIHE CHEMICALS CO LTD | 2014-06-11 | — | — | CN | disclosed |
| US-5028522-A | High speed, storage stable, nonfogging, selenium compounds | FUJI PHOTO FILM CO., LTD. (JP) | 1991-07-02 | — | — | US | disclosed |
| US-4845020-A | ANTIFOGGANT, SENSITIVITY | FUJI PHOTO FILM CO., LTD. (JP) | 1989-07-04 | — | — | US | disclosed |
| US-4804618-A | BLEACHING | FUJI PHOTO FILM CO., LTD. (JP) | 1989-02-14 | — | — | US | disclosed |
| US-4554246-A | THIOTETREAZOLYLPHENYL CARBAMATE | FUJI PHOTO FILM CO., LTD. (JP) | 1985-11-19 | — | — | US | disclosed |
| US-4179296-A | CONTAINING A BENZIMIDAZOLOCARBOCYANINE DYE AND AT LEAST ONE OTHER CYANINE DYE | FUJI PHOTO FILM CO., LTD. (JP) | 1979-12-18 | — | — | US | disclosed |
| US-4144071-A | DISPERSION IN HYDROPHILIC COLLOID LAYER OF HYDROQUINONE REDUCING AGENT AND COMPOUND CONTAINING HETEROCYCLICTHIO GROUP | FUJI PHOTO FILM CO., LTD. (JP) | 1979-03-13 | — | — | US | disclosed |
| US-4015988-A | SILVER HALIDE EMULSION, DYE COUPLERS | FUJI PHOTO FILM CO., LTD. (JA) | 1977-04-05 | — | — | US | disclosed |
| US-3961963-A | HYDROQUINONE DERIVATIVE, DEVELOPMENT INHIBITOR | FUJI PHOTO FILM CO., LTD. (JA) | 1976-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250136537-A1 | SYSTEM AND PROCESS FOR CONTINUOUS PREPARATION OF meta-CRESOL BY NOx | NOX1, NOX5, NOXO1 | CYP3A4 277/4885TDP1 1806/4885CD44 4854/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.