Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 11/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9901968 | 0.89 | KCNA5 (0.58) | KCNA5KCNH2MEN1KMT2A | |
| SCHEMBL9902165 | 0.89 | KCNA5 (0.58) | KCNA5KCNH2MEN1KMT2A | |
| SCHEMBL1242364 | 0.84 | KCNA5 (0.53) | KCNA5KCNH2 | |
| SCHEMBL1242944 | 0.84 | KCNA5 (0.53) | KCNA5KCNH2 | |
| SCHEMBL1242367 | 0.84 | KCNA5 (0.53) | KCNA5KCNH2 | |
| SCHEMBL1240785 | 0.82 | KCNA5 (0.53) | KCNA5KCNH2MEN1ALDH1A1KMT2A | |
| SCHEMBL1240787 | 0.82 | KCNA5 (0.53) | KCNA5KCNH2MEN1ALDH1A1KMT2A | |
| SCHEMBL1243430 | 0.81 | KCNA5 (0.53) | KCNA5KCNH2 | |
| SCHEMBL1243433 | 0.81 | KCNA5 (0.53) | KCNA5KCNH2 | |
| SCHEMBL1242273 | 0.81 | KCNA5 (0.56) | KCNA5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080090794-A1 | Potassium Channel Inhibitors | MERCK SHARP & DOHME LLC | 2008-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080090794-A1 | Potassium Channel Inhibitors | KCNJ2, KCNQ2, KCNH2 | KCNA5 11/4885KCNH2 3/4885MEN1 2152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.