Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.41 |
| ▸ | RAB9A | P51151 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 2/20 | 0.38 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.38 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 4/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.36 |
| ▸ | RELA | Q04206 | 2/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10234775 | 0.83 | NPC1 (0.45) | NPC1RAB9AMEN1KMT2AMTOR | |
| SCHEMBL15026251 | 0.81 | NPC1 (0.40) | NPC1RAB9AMEN1KMT2AMTOR | |
| SCHEMBL15026255 | 0.81 | MTOR (0.43) | NPC1RAB9AMEN1KMT2AMTOR | |
| SCHEMBL30716 | 0.79 | MTOR (0.43) | MTORRPTORMLST8KDR | |
| SCHEMBL39794 | 0.77 | WNT3A (0.37) | NPC1RAB9AMEN1KMT2AMTOR | |
| SCHEMBL41447 | 0.77 | MTOR (0.43) | MTORRPTORMLST8MAPTALOX5AP | |
| SCHEMBL31031 | 0.77 | MTOR (0.45) | MTORRPTORMLST8MAPT | |
| SCHEMBL15007449 | 0.77 | MTOR (0.42) | MTORRPTORMLST8MAPTALOX5AP | |
| SCHEMBL30450 | 0.76 | ALDH1A1 (0.37) | NPC1RAB9AMEN1KMT2AMTOR | |
| SCHEMBL17787548 | 0.76 | MTOR (0.41) | MTORRPTORMLST8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012027234-A1 | FUSED TRICYCLIC INHIBITORS OF MAMMALIAN TARGET OF RAPAMYCIN | SCHERING CORPORATION (US) | 2012-03-01 | — | — | WO | disclosed |