Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | MAOA | P21397 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3811441 | 0.85 | BAZ2B (0.59) | BAZ2BNPC1RAB9AMAOACYP1A2 | |
| SCHEMBL10905839 | 0.85 | BAZ2B (0.55) | BAZ2BNPC1RAB9AMAOACYP1A2 | |
| SCHEMBL10908115 | 0.84 | BAZ2B (0.54) | BAZ2BNPC1RAB9AMAOACYP1A2 | |
| Trimethylammonium SCHEMBL10341484 | 0.82 | BAZ2B (0.56) | BAZ2BNPC1RAB9AMAOACYP1A2 | |
| SCHEMBL5342349 | 0.81 | BAZ2B (0.55) | BAZ2BNPC1RAB9AMAOACYP1A2 | |
| SCHEMBL10750989 | 0.80 | BAZ2B (0.50) | BAZ2BNPC1RAB9AMAOACYP1A2 | |
| SCHEMBL10750981 | 0.79 | ITGB3 (0.51) | BAZ2BNPC1RAB9AMAOACYP1A2 | |
| SCHEMBL10341519 | 0.78 | BAZ2B (0.48) | BAZ2BNPC1RAB9AMAOACYP1A2 | |
| SCHEMBL10341491 | 0.77 | NQO2 (0.48) | BAZ2BNPC1RAB9AMAOACYP1A2 | |
| SCHEMBL5343888 | 0.77 | BAZ2B (0.47) | BAZ2BNPC1RAB9AMAOACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910338-A2 | HETEROTETRACYCLIC COMPOUNDS AS TPO MIMETICS | IRM, LLC (BM) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007009120-A2 | HETEROTETRACYCLIC COMPOUNDS AS TPO MIMETICS | IRM LLC (BM) | 2007-01-18 | — | — | WO | disclosed |