Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 2/20 | 0.42 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.42 |
| ▸ | ITGAV | P06756 | 1/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.42 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.42 |
| ▸ | ITGAL | P20701 | 1/20 | 0.42 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | IDE | P14735 | 2/20 | 0.33 |
| ▸ | RIN1 | Q13671 | 2/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.33 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.33 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31124620 | 1.00 | ITGB1 (0.42) | ITGB1ITGA5ITGB3ITGB2ITGAV | |
| SCHEMBL31124633 | 1.00 | ITGB1 (0.42) | ITGB1ITGA5ITGB3ITGB2ITGAV | |
| SCHEMBL10650169 | 0.98 | ITGB1 (0.41) | ITGB1ITGA5ITGB3ITGB2ITGAV | |
| SCHEMBL10640864 | 0.92 | FFAR4 (0.42) | ITGB1ITGA5ITGB3ITGB2ITGAV | |
| SCHEMBL25255061 | 0.89 | ITGB1 (0.40) | ITGB1ITGA5ITGB3ITGB2ITGAV | |
| SCHEMBL197943 | 0.89 | ITGB1 (0.40) | ITGB1ITGA5ITGB3ITGB2ITGAV | |
| SCHEMBL2582193 | 0.87 | TDP1 (0.45) | ITGB1ITGA5ITGB3ITGB2ITGAV | |
| SCHEMBL27353938 | 0.83 | MGLL (0.37) | ITGB1ITGA5ITGB3ITGB2ITGAV | |
| SCHEMBL10645217 | 0.83 | GAA (0.38) | MGLLCD274IRAK4 | |
| SCHEMBL10650173 | 0.81 | MGLL (0.37) | ITGB1ITGA5ITGB3ITGB2ITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0238088-B1 | IMPROVED PROCESS FOR THE PREPARATION OF DIHYDRO-1H-PYRROLIZINE-3,5-(2H,6H)-DIONE | WARNER-LAMBERT COMPANY (US) | 1990-10-31 | — | — | EP | claimed |
| EP-0095278-B1 | 5-OXO-2-PYRROLIDINEPROPANOIC ACID DERIVATIVES AND THEIR PRODUCTION | WARNER-LAMBERT COMPANY (US) | 1988-11-30 | — | — | EP | claimed |
| EP-0164852-B1 | 1-(SUBSTITUTED-ARYL)-DIHYDRO-1H-PYRROLIZINE-3,5-(2H,6H-)DIONES, A PROCESS FOR PRODUCING THE COMPOUNDS AND A PHARMACEUTICAL COMPOSITION COMPRISING THE COMPOUNDS | WARNER-LAMBERT COMPANY (US) | 1988-07-06 | — | — | EP | claimed |
| EP-0238088-A2 | Improved process for the preparation of dihydro-1H-pyrrolizine-3,5-(2H,6H)-dione | WARNER-LAMBERT COMPANY (US) | 1987-09-23 | — | — | EP | claimed |
| US-4663464-A | Process for the preparation of dihydro-1H-pyrrolizine-3,5-(2H,6H)-dione | WARNER-LAMBERT COMPANY (US) | 1987-05-05 | — | — | US | claimed |
| EP-0164852-A1 | 1-(Substituted-aryl)-Dihydro-1H-pyrrolizine-3,5-(2H,6H-)diones, a process for producing the compounds and a pharmaceutical composition comprising the compounds | WARNER-LAMBERT COMPANY (US) | 1985-12-18 | — | — | EP | claimed |
| US-11981661-B2 | Heterocyclic compounds | HOFFMANN-LA ROCHE INC. (US) | 2024-05-14 | — | — | US | disclosed |
| EP-4208456-A1 | HETEROCYCLIC COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2023-07-12 | — | — | EP | disclosed |
| CN-115989228-A | Heterocyclic compounds | 豪夫迈·罗氏有限公司 | 2023-04-18 | — | — | CN | disclosed |
| US-20220098176-A1 | HETEROCYCLIC COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2022-03-31 | — | — | US | disclosed |
| US-8445081-B2 | Polarizing plate protective film, polarizing plate and liquid crystal display device | KONICA MINOLTA OPTO, INC. (JP) | 2013-05-21 | — | — | US | disclosed |
| US-7414071-B2 | Methods of treatment with selective EP4 receptor agonists | PFIZER INC. (US) | 2008-08-19 | — | — | US | disclosed |
| US-7414071-B2 | Methods of treatment with selective EP4 receptor agonists | PFIZER INC. (US) | 2008-08-19 | — | — | US | disclosed |
| EP-0110575-A1 | 1-Aroyl-5-oxo-2-pyrrolidinepropanoic acids and related esters | WARNER-LAMBERT COMPANY (US) | 1984-06-13 | — | — | EP | disclosed |
| US-4452990-A | TREATMENT OF SENILITY, AMNESIA AND MOTIVATION | WARNER-LAMBERT COMPANY (US) | 1984-06-05 | — | — | US | disclosed |
| EP-0095278-A2 | 5-Oxo-2-pyrrolidinepropanoic acid derivatives and their production | WARNER-LAMBERT COMPANY (US) | 1983-11-30 | — | — | EP | disclosed |
| EP-0095278-A2 | 5-Oxo-2-pyrrolidinepropanoic acid derivatives and their production | WARNER-LAMBERT COMPANY (US) | 1983-11-30 | — | — | EP | disclosed |
| EP-0095278-A2 | 5-Oxo-2-pyrrolidinepropanoic acid derivatives and their production | WARNER-LAMBERT COMPANY (US) | 1983-11-30 | — | — | EP | disclosed |
| US-4372966-A | TREATMENT OF SENILITY, ENHANCING MEMORY, REVERSAL OF AMNESIA CAUSED BY ELECTRIC SHOCK | WARNER-LAMBERT COMPANY (US) | 1983-02-08 | — | — | US | disclosed |
| EP-0048132-A2 | The use of dihydro-1H-pyrrolizine-3,5(2H,6H)-dione as a cognition activator, pharmaceutical compositions containing that compound, and the production of such compositions | WARNER-LAMBERT COMPANY (US) | 1982-03-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220098176-A1 | HETEROCYCLIC COMPOUNDS | CBR3, BRIX1, CCNY | ITGB1 3738/4885ITGA5 3646/4885ITGB3 3207/4885 |
| US-11981661-B2 | Heterocyclic compounds | CBR3, BRIX1, CCNY | ITGB1 3738/4885ITGA5 3646/4885ITGB3 3207/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.