Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.54 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.54 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.46 |
| ▸ | DOT1L | Q8TEK3 | 2/20 | 0.45 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | PRKCG | P05129 | 1/20 | 0.39 |
| ▸ | PRKCB | P05771 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4581753 | 0.81 | ROCK2 (0.50) | ROCK2PIM1PIM3PARP1L3MBTL1 | |
| SCHEMBL4578786 | 0.79 | ROCK2 (0.45) | ROCK2PIM1PIM3F10TSHR | |
| SCHEMBL2640132 | 0.78 | F10 (0.59) | ROCK2PIM1PIM3RORCF10 | |
| SCHEMBL31116766 | 0.76 | BIRC5 (0.47) | TRAP1DOT1LBIRC5HSP90AA1HSP90AB1 | |
| SCHEMBL4792570 | 0.75 | RORC (0.60) | RORCLMNA | |
| Hydrochloric Acid SCHEMBL10637882 | 0.75 | ROCK2 (0.66) | ROCK2PIM1PIM3BIRC5F10 | |
| SCHEMBL5661104 | 0.74 | BIRC5 (0.56) | TRAP1DOT1LBIRC5HSP90AA1HSP90AB1 | |
| SCHEMBL31116722 | 0.74 | BIRC5 (0.56) | TRAP1DOT1LBIRC5HSP90AA1HSP90AB1 | |
| SCHEMBL30928942 | 0.74 | NPC1 (0.46) | ROCK2PIM1PIM3TRAP1BIRC5 | |
| SCHEMBL30637639 | 0.74 | NPC1 (0.46) | ROCK2PIM1PIM3TRAP1BIRC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080119457-A1 | Benzene, Pyridine, and Pyridazine Derivatives | SERENEX, INC. | 2008-05-22 | — | — | US | claimed |
| WO-2008024978-A2 | TETRAHYDROINDOLONE AND TETRAHYDROINDAZOLONE DERIVATIVES | SERENEX, INC. (US) | 2008-02-28 | — | — | WO | claimed |
| EP-2662367-B1 | NOVEL INDOLE OR INDAZOLE DERIVATIVE OR SALT THEREOF | TAIHO PHARMACEUTICAL CO LTD (JP) | 2016-08-17 | — | — | EP | disclosed |
| US-9273045-B2 | Azabicyclo compound and salt thereof | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2016-03-01 | — | — | US | disclosed |
| US-9273045-B2 | Azabicyclo compound and salt thereof | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2016-03-01 | — | — | US | disclosed |
| US-9120780-B2 | Indole or indazole derivative or salt thereof | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2015-09-01 | — | — | US | disclosed |
| US-9120780-B2 | Indole or indazole derivative or salt thereof | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2015-09-01 | — | — | US | disclosed |
| US-20140303162-A1 | AZABICYCLO COMPOUND AND SALT THEREOF | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2014-10-09 | — | — | US | disclosed |
| US-20140303162-A1 | AZABICYCLO COMPOUND AND SALT THEREOF | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2014-10-09 | — | — | US | disclosed |
| US-8779142-B2 | Azabicyclo compound and salt thereof | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2014-07-15 | — | — | US | disclosed |
| US-8779142-B2 | Azabicyclo compound and salt thereof | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2014-07-15 | — | — | US | disclosed |
| US-20130289072-A1 | NOVEL INDOLE OR INDAZOLE DERIVATIVE OR SALT THEREOF | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2013-10-31 | — | — | US | disclosed |
| EP-2452940-A1 | AZABICYCLO COMPOUND AND SALT THEREOF | Taiho Pharmaceutical Co., Ltd. (JP) | 2012-05-16 | — | — | EP | disclosed |
| US-20120108589-A1 | AZABICYCLO COMPOUND AND SALT THEREOF | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2012-05-03 | — | — | US | disclosed |
| US-20120108589-A1 | AZABICYCLO COMPOUND AND SALT THEREOF | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2012-05-03 | — | — | US | disclosed |
| WO-2011004610-A1 | AZABICYCLO COMPOUND AND SALT THEREOF | 大鵬薬品工業株式会社 (JP) | 2011-01-13 | — | — | WO | disclosed |
| US-20080119457-A1 | Benzene, Pyridine, and Pyridazine Derivatives | SERENEX, INC. | 2008-05-22 | — | — | US | disclosed |
| US-20080119457-A1 | Benzene, Pyridine, and Pyridazine Derivatives | SERENEX, INC. | 2008-05-22 | — | — | US | disclosed |
| US-20080119457-A1 | Benzene, Pyridine, and Pyridazine Derivatives | SERENEX, INC. | 2008-05-22 | — | — | US | disclosed |
| WO-2008024978-A2 | TETRAHYDROINDOLONE AND TETRAHYDROINDAZOLONE DERIVATIVES | SERENEX, INC. (US) | 2008-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140303162-A1 | AZABICYCLO COMPOUND AND SALT THEREOF | HSP90AB1, HSP90AB2P, HSP90AA1 | ROCK2 614/4885PIM1 4623/4885PIM3 4337/4885 |
| US-20130289072-A1 | NOVEL INDOLE OR INDAZOLE DERIVATIVE OR SALT THEREOF | HSP90AB1, HSP90AA1, HSP90AB2P | ROCK2 553/4885PIM1 1587/4885PIM3 683/4885 |
| US-20120108589-A1 | AZABICYCLO COMPOUND AND SALT THEREOF | HSP90AB1, HSP90AB2P, HSP90AA1 | ROCK2 614/4885PIM1 4623/4885PIM3 4337/4885 |
| US-20080119457-A1 | Benzene, Pyridine, and Pyridazine Derivatives | MKI67, CCNB1, RB1 | ROCK2 2857/4885PIM1 1374/4885PIM3 2773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.