Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 2/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GPR52 | Q9Y2T5 | 2/20 | 0.37 |
| ▸ | ATF1 | P18846 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27459331 | 0.80 | HTT (0.42) | HTTHSD17B10PLA2G10PLA2G2ALIMK1 | |
| SCHEMBL45808 | 0.78 | L3MBTL1 (0.41) | HTTHSD17B10L3MBTL1PLA2G10PLA2G2A | |
| SCHEMBL28681774 | 0.75 | PLA2G2A (0.57) | HSD17B10L3MBTL1PLA2G10PLA2G2ACDC7 | |
| SCHEMBL1720768 | 0.72 | L3MBTL1 (0.46) | HTTHSD17B10L3MBTL1KDM4ECD38 | |
| SCHEMBL30238408 | 0.72 | L3MBTL1 (0.46) | HTTHSD17B10L3MBTL1RPS6KB1AURKA | |
| SCHEMBL25251294 | 0.72 | L3MBTL1 (0.46) | HTTHSD17B10L3MBTL1CDC7RPS6KB1 | |
| SCHEMBL3957624 | 0.71 | HTT (0.50) | HTTHSD17B10KDM4EGPR52NR3C2 | |
| SCHEMBL17981949 | 0.71 | L3MBTL1 (0.44) | HTTHSD17B10L3MBTL1LIMK1KDM4E | |
| SCHEMBL22717306 | 0.71 | PLA2G2A (0.45) | HSD17B10L3MBTL1PLA2G10PLA2G2ACDC7 | |
| SCHEMBL28295798 | 0.71 | PLA2G2A (0.45) | HSD17B10L3MBTL1PLA2G10PLA2G2ACDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2591354-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| EP-2590656-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012054110-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-04-26 | — | — | WO | disclosed |
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |