Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 3/20 | 0.54 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.51 |
| ▸ | FYN | P06241 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.47 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | USP7 | Q93009 | 2/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12518227 | 0.83 | CYP2A6 (0.62) | MAP4K4LRRK2FYNMEN1NPC1 | |
| SCHEMBL4580917 | 0.82 | MAP4K4 (0.47) | MAP4K4FYNUSP7CHEK2 | |
| SCHEMBL28032602 | 0.82 | CYP2A6 (0.57) | MAP4K4LRRK2FYNKDM4EHPGD | |
| SCHEMBL4582434 | 0.81 | ADORA1 (0.49) | MAP4K4LRRK2FYNMEN1NPC1 | |
| Hydrochloric Acid SCHEMBL4359853 | 0.81 | CYP2A6 (0.55) | MAP4K4LRRK2FYNKDM4EHPGD | |
| SCHEMBL16456342 | 0.79 | MAP4K4 (0.58) | MAP4K4LRRK2FYNUSP7CHEK2 | |
| SCHEMBL13968119 | 0.79 | MAP4K4 (0.54) | MAP4K4LRRK2FYNNPSR1MEN1 | |
| SCHEMBL29857960 | 0.79 | MAP4K4 (0.54) | MAP4K4LRRK2FYNNPSR1MEN1 | |
| SCHEMBL18356522 | 0.79 | MAP4K4 (0.54) | MAP4K4LRRK2FYNMEN1NPC1 | |
| SCHEMBL625738 | 0.76 | NTRK1 (0.50) | MAP4K4FYNUSP7CHEK2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8362017-B2 | N-[5-chloro-2-(methyloxy)phenyl]-2-{[3-(1H-tetrazol-1-yl)phenyl]oxy}acetamide; antiproliferative agents; protein kinase inhibitors; drug screening | EXELIXIS, INC. (US) | 2013-01-29 | — | — | US | disclosed |
| US-20080096892-A1 | C-Kit Modulators And Methods Of Use | EXELIXIS, INC. (US) | 2008-04-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080096892-A1 | C-Kit Modulators And Methods Of Use | KIT, PRKCH, PRKCB | MAP4K4 354/4885LRRK2 1093/4885FYN 1657/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.