Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 3/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.49 |
| ▸ | JAK3 | P52333 | 13/20 | 0.49 |
| ▸ | JAK2 | O60674 | 10/20 | 0.49 |
| ▸ | TYK2 | P29597 | 10/20 | 0.49 |
| ▸ | JAK1 | P23458 | 9/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.49 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 2/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.42 |
| ▸ | CHUK | O15111 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2693625 | 0.83 | JAK3 (0.74) | MAPK9MAPK10JAK3JAK2TYK2 | |
| SCHEMBL4579455 | 0.79 | DYRK1A (0.66) | DYRK1ASRC | |
| SCHEMBL31208500 | 0.78 | HCAR3 (0.49) | JAK3JAK2TYK2JAK1SYK | |
| SCHEMBL2479839 | 0.76 | JAK3 (0.58) | JAK3JAK2TYK2JAK1IRAK4 | |
| SCHEMBL2695782 | 0.74 | JAK3 (0.74) | MAPK9MAPK10JAK3JAK2TYK2 | |
| SCHEMBL4581333 | 0.73 | MAPK10 (0.39) | MAPK9MAPK10DYRK1AJAK3JAK2 | |
| SCHEMBL2713949 | 0.73 | JAK3 (0.53) | JAK3JAK2TYK2JAK1IRAK4 | |
| SCHEMBL12321864 | 0.72 | JAK3 (0.73) | JAK3JAK2TYK2JAK1IRAK4 | |
| SCHEMBL4581579 | 0.72 | ALDH1A1 (0.42) | MAPK9MAPK10MAPK1 | |
| SCHEMBL16331603 | 0.71 | DYRK1A (0.44) | DYRK1ABRAFPRKD3ABL1PRKCG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080076800-A1 | Benzene, Pyridine, and Pyridazine Derivatives | SERENEX, INC. | 2008-03-27 | — | — | US | claimed |
| WO-2008024963-A1 | BENZENE, PYRIDINE, AND PYRIDAZINE DERIVATIVES | SERENEX, INC. (US) | 2008-02-28 | — | — | WO | claimed |
| US-20080076800-A1 | Benzene, Pyridine, and Pyridazine Derivatives | SERENEX, INC. | 2008-03-27 | — | — | US | disclosed |
| US-20080076800-A1 | Benzene, Pyridine, and Pyridazine Derivatives | SERENEX, INC. | 2008-03-27 | — | — | US | disclosed |
| US-20080076800-A1 | Benzene, Pyridine, and Pyridazine Derivatives | SERENEX, INC. | 2008-03-27 | — | — | US | disclosed |
| WO-2008024963-A1 | BENZENE, PYRIDINE, AND PYRIDAZINE DERIVATIVES | SERENEX, INC. (US) | 2008-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076800-A1 | Benzene, Pyridine, and Pyridazine Derivatives | RB1, MKI67, CCNB1 | MAPK9 3008/4885MAPK10 3262/4885DYRK1A 2145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.